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  • Continuation of clozapine treatment: practice makes perfect

    Author(s)
    Whiskey, Eromina
    Wykes, Til
    Duncan-McConnell, Denise
    Haworth, Elke
    Walsh, Nick
    Hastilow, Sarah
    Griffith University Author(s)
    McConnell, Denise
    Year published
    2003
    Metadata
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    Abstract
    AIMS AND METHOD The study aimed to identify the predictors of drop-out from clozapine treatment by examining the demographic and clinical characteristics of patients registered on clozapine within a 6-month period in one NHS Trust. RESULTS During the study period, 54 patients were registered and began clozapine treatment and 31% had discontinued within 6 months. Two people died and the remainder discontinued because of non-compliance or side-effects, including neutropenia. Two factors were predictive: the age of the patient (older patients were more likely to discontinue) and the hospital where the initial registration ...
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    AIMS AND METHOD The study aimed to identify the predictors of drop-out from clozapine treatment by examining the demographic and clinical characteristics of patients registered on clozapine within a 6-month period in one NHS Trust. RESULTS During the study period, 54 patients were registered and began clozapine treatment and 31% had discontinued within 6 months. Two people died and the remainder discontinued because of non-compliance or side-effects, including neutropenia. Two factors were predictive: the age of the patient (older patients were more likely to discontinue) and the hospital where the initial registration was made. CLINICAL IMPLICATIONS Neither ethnicity, previous registration nor the individual prescriber are a bar to successful persistence with clozapine. However, one set of hospitals with a history of evidence-based practice and high clozapine prescribing was more successful in retaining patients on maintenance treatment. Although specific dataare needed to identify more subtle contributing factors to continuation, it is clear that there is scope for improving the rate of persistence with clozapine treatment.
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    Journal Title
    Psychiatric Bulletin
    Volume
    27
    DOI
    https://doi.org/10.1192/pb.27.6.211
    Subject
    Clinical Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/32103
    Collection
    • Journal articles

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