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dc.contributor.authorS. Rosenberg, Michael
dc.contributor.authorSubramanian, Sankar
dc.contributor.authorKumar, Sudhir
dc.date.accessioned2017-05-03T13:47:22Z
dc.date.available2017-05-03T13:47:22Z
dc.date.issued2003
dc.identifier.issn07374038
dc.identifier.doi10.1093/molbev/msg113
dc.identifier.urihttp://hdl.handle.net/10072/32109
dc.description.abstractSignificant transition/transversion mutation bias is a well-appreciated aspect of mammalian nuclear genomes; however, patterns of bias among genes within a genome and among species remain largely uncharacterized. Understanding these patterns is important for understanding similarities and differences in mutational patterns among genomes and genomic regions. Therefore, we have conducted an analysis of 7,587 pairs of sequences of 4,347 mammalian protein-coding genes from seven species (human, mouse, rat, cow, sheep, pig, and macaque) and from the introns of 51 gene pairs and multiple intergenic regions (37 kbp, 52 kbp and 65 kbp) from the human, chimpanzee, and baboon genomes. Our analyses show that genes and regions with widely varying base composition exhibit uniformity of transition mutation rate both within and among mammalian lineages, as long as the transitional mutations caused by CpG hypermutability are excluded. The estimates show no relationship to potential intrachromosomal or interchromosomal effects. This uniformity points to similarity in point mutation processes in genomic regions with substantially different GC-content biases.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom988
dc.relation.ispartofpageto993
dc.relation.ispartofissue6
dc.relation.ispartofjournalMolecular Biology and Evolution
dc.relation.ispartofvolume20
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchEvolutionary Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0603
dc.subject.fieldofresearchcode0604
dc.titlePatterns of Transitional Mutation Biases Within and Among Mammalian Genomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-13T03:20:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorSankarasubramanian, Sankar


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