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  • Rates of Platination of AG and GA containing double-stranded oliqonucleotides:effect of chloride concentration.

    Author
    Davies, Murray
    Berners-Price, Sue
    Hambley, Trevor W.
    Year published
    2000
    Metadata
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    Abstract
    The kinetics of the reactions between 15N-labelled cisplatin and 14-base pair duplex oligonucleotides with either 5'-AG-3' or 5'-GA-3' groupings as the principal platination site are examined in the presence of 60-80 mM chloride by [1H,15N] HSQC 2D NMR spectroscopy. The presence of chloride at these concentrations results in a five-fold decrease in the rate of hydrolysis of cisplatin to cis-[PtCl(NH3)2(OH2)]+ and a two- to twenty-fold decrease in the rate of monofunctional adduct formation. The effects on the rate of closure from monofunctional to bifunctional adducts are less well established but some of these rates appear not to be significantly reduced by the presence of added chloride. The results provide a caution that the use of chloride to quench platination reactions may not be fully effective.
    Journal Title
    Journal of Inorganic Biochemistry
    Volume
    79
    DOI
    https://doi.org/10.1016/S0162-0134(99)00180-4
    Subject
    HISTORY AND ARCHAEOLOGY
    Publication URI
    http://hdl.handle.net/10072/3213
    Collection
    • Journal articles

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