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dc.contributor.authorDavies, MS
dc.contributor.authorBerners-Price, SJ
dc.contributor.authorHambley, TW
dc.date.accessioned2017-09-24T22:41:57Z
dc.date.available2017-09-24T22:41:57Z
dc.date.issued2000
dc.date.modified2007-03-13T21:51:43Z
dc.identifier.issn0162-0134
dc.identifier.doi10.1016/S0162-0134(99)00180-4
dc.identifier.urihttp://hdl.handle.net/10072/3213
dc.description.abstractThe kinetics of the reactions between 15N-labelled cisplatin and 14-base pair duplex oligonucleotides with either 5'-AG-3' or 5'-GA-3' groupings as the principal platination site are examined in the presence of 60-80 mM chloride by [1H,15N] HSQC 2D NMR spectroscopy. The presence of chloride at these concentrations results in a five-fold decrease in the rate of hydrolysis of cisplatin to cis-[PtCl(NH3)2(OH2)]+ and a two- to twenty-fold decrease in the rate of monofunctional adduct formation. The effects on the rate of closure from monofunctional to bifunctional adducts are less well established but some of these rates appear not to be significantly reduced by the presence of added chloride. The results provide a caution that the use of chloride to quench platination reactions may not be fully effective.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeUSA
dc.relation.ispartofpagefrom167
dc.relation.ispartofpageto172
dc.relation.ispartofjournalJournal of Inorganic Biochemistry
dc.relation.ispartofvolume79
dc.subject.fieldofresearchInorganic chemistry
dc.subject.fieldofresearchTheoretical and computational chemistry
dc.subject.fieldofresearchOther chemical sciences
dc.subject.fieldofresearchHistory, heritage and archaeology
dc.subject.fieldofresearchcode3402
dc.subject.fieldofresearchcode3407
dc.subject.fieldofresearchcode3499
dc.subject.fieldofresearchcode43
dc.titleRates of Platination of AG and GA containing double-stranded oliqonucleotides:effect of chloride concentration.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.date.issued2000
gro.hasfulltextNo Full Text
gro.griffith.authorBerners-Price, Sue J.


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