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dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorW. Hambley, Trevoren_US
dc.date.accessioned2017-04-24T10:57:27Z
dc.date.available2017-04-24T10:57:27Z
dc.date.issued2000en_US
dc.date.modified2007-03-13T21:51:43Z
dc.identifier.issn01620134en_US
dc.identifier.urihttp://hdl.handle.net/10072/3213
dc.description.abstractThe kinetics of the reactions between 15N-labelled cisplatin and 14-base pair duplex oligonucleotides with either 5'-AG-3' or 5'-GA-3' groupings as the principal platination site are examined in the presence of 60-80 mM chloride by [1H,15N] HSQC 2D NMR spectroscopy. The presence of chloride at these concentrations results in a five-fold decrease in the rate of hydrolysis of cisplatin to cis-[PtCl(NH3)2(OH2)]+ and a two- to twenty-fold decrease in the rate of monofunctional adduct formation. The effects on the rate of closure from monofunctional to bifunctional adducts are less well established but some of these rates appear not to be significantly reduced by the presence of added chloride. The results provide a caution that the use of chloride to quench platination reactions may not be fully effective.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Scienceen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/505772/description#descriptionen_AU
dc.relation.ispartofpagefrom167en_US
dc.relation.ispartofpageto172en_US
dc.relation.ispartofjournalJournal of Inorganic Biochemistryen_US
dc.relation.ispartofvolume79en_US
dc.subject.fieldofresearchHISTORY AND ARCHAEOLOGYen_US
dc.subject.fieldofresearchcode210000en_US
dc.titleRates of Platination of AG and GA containing double-stranded oliqonucleotides:effect of chloride concentration.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.rights.copyrightCopyright 2000 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.en_AU
gro.date.issued2000
gro.hasfulltextNo Full Text


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