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dc.contributor.authorKeech, A.
dc.contributor.authorGrieve, S.
dc.contributor.authorPatel, A.
dc.contributor.authorGriffiths, K.
dc.contributor.authorSkilton, M.
dc.contributor.authorWatts, Gerald F.
dc.contributor.authorMarwick, T.
dc.contributor.authorGroshens, M.
dc.contributor.authorCelermajer, D.
dc.contributor.authorHamilton-Craig, I.
dc.contributor.authoret al.
dc.date.accessioned2018-08-02T23:55:38Z
dc.date.available2018-08-02T23:55:38Z
dc.date.issued2005
dc.identifier.issn07423071
dc.identifier.doi10.1111/j.1464-5491.2005.01688.x
dc.identifier.urihttp://hdl.handle.net/10072/32144
dc.description.abstractAim: Cardiovascular disease (CVD) rates are substantially higher among patients with Type 2 diabetes than in the general population. The objective of this study was to identify the determinants of carotid intima media thickness (IMT) in patients with Type 2 diabetes. Methods: We measured the thickness of the intima media layer of the carotid artery, a strong predictor of the risk of future vascular events, in 397 Type 2 diabetic patients drawn from the Fenofibrate Intervention and Event Lowering in Diabetes study, prior to treatment allocation. Results: The mean IMT was 0.78 mm [interquartile range (IQR) 0.23 mm], and the maximum IMT was 1.17 mm (IQR 0.36 mm). By multivariate analysis, age, sex, duration of diabetes, triglycerides, and total cholesterol were independently correlated with IMT, as was urine albumin–creatinine ratio (ACR) (P < 0.001). The effect of ACR on IMT was further examined by tertile. Clinically significant differences in IMT were associated with ACR > 0.65 mg/mmol, approximately one‐fifth the standard clinical threshold for microalbuminuria (P < 0.01). Long‐term diabetes, independent of other parameters, was associated with a 50% increase in age‐related thickening. Conclusions: IMT in people with Type 2 diabetes is independently and continuously related to urine albumin levels and to the duration of diabetes. These results support previous data linking urine albumin measurements within the normal range with increased ischaemic cardiac mortality in the setting of Type 2 diabetes, and strongly suggest that urine albumin levels within this range should trigger a formal evaluation for CVD.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1558
dc.relation.ispartofpageto1565
dc.relation.ispartofissue11
dc.relation.ispartofjournalDiabetic Medicine
dc.relation.ispartofvolume22
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1701
dc.titleUrinary albumin levels in the normal range determine arterial wall thickness in adults with Type 2 diabetes: a FIELD substudy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2014-10-10T01:55:54Z
gro.hasfulltextNo Full Text
gro.griffith.authorHamilton-Craig, Ian


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