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dc.contributor.authorKennedy, Karenen_US
dc.contributor.authorMacova, Miroslavaen_US
dc.contributor.authorE. Bartkow, Michaelen_US
dc.contributor.authorHawker, Darrylen_US
dc.contributor.authorZhao, Binen_US
dc.contributor.authorS. Denison, Michaelen_US
dc.contributor.authorMueller, Jochen F.en_US
dc.date.accessioned2017-05-03T11:24:32Z
dc.date.available2017-05-03T11:24:32Z
dc.date.issued2010en_US
dc.date.modified2010-09-22T06:54:47Z
dc.identifier.issn13091042en_US
dc.identifier.doi10.5094/APR.2010.008en_AU
dc.identifier.urihttp://hdl.handle.net/10072/32194
dc.description.abstractThere has been relatively little bioanalytical effect based monitoring conducted using samples derived from polyurethane foam (PUF) passive air samplers. Combining these techniques may provide a more convenient and cost effective means of monitoring the potential for biological effects resulting from exposure to complex mixtures in a range of scenarios. Seasonal polycyclic aromatic hydrocarbon (PAH) levels were monitored at sites around Australia using direct chemical analysis. In addition, both indirect acting genotoxicity (umuC assay) and aryl hydrocarbon receptor (AhR) activity (chemically activated fluorescent gene expression [CAFLUX assay]), which are effects potentially relevant to subsequent carcinogenesis for these compounds, were measured. The levels of PAHs as well as genotoxicity and AhR activity were all higher in winter compared to summer and for sites in urban capital cities compared to other locations. Statistically significant relationships were found between the levels of PAHs and both genotoxicity and AhR activity. The dominant contributors to the total AhR activity, were found to be for compounds which are not resistant to H2SO4/silica gel treatment and were relatively rapidly metabolised that is consistent with a PAH type response. Relative potency estimates for individual PAHs determined for the first time on the CAFLUX assay were used to estimate the proportion of total AhR activity (= 3.0%) accounted by PAHs monitored. Observed responses are thus largely due to non-quantified AhR active compounds.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent403791 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherTurkish National Committee for Air Pollution Research and Control (TUNCAP)en_US
dc.publisher.placeTurkeyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom50en_US
dc.relation.ispartofpageto58en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalAtmospheric Pollution Researchen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchEnvironmental Chemistry (incl. Atmospheric Chemistry)en_US
dc.subject.fieldofresearchcode039901en_US
dc.titleEffect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplersen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright remains with the authors 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal's website or contact the authors.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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