Synthesis of N-Propargyl Iminosugar Scaffolds for Compound Library Generation using Click Chemistry
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We have developed an efficient synthesis of N-propargyl iminosugars for use in diversity-oriented library development. Through a common, crystalline intermediate both piperidine and azepane scaffolds can be prepared with an alkyne functional group, allowing for further elaboration through reaction with azides.
Australian Journal of Chemistry
Biologically Active Molecules