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dc.contributor.authorBurne, THJ
dc.contributor.authorJohnston, ANB
dc.contributor.authorWilkinson, LS
dc.contributor.authorKendrick, KM
dc.date.accessioned2017-05-03T14:27:33Z
dc.date.available2017-05-03T14:27:33Z
dc.date.issued2010
dc.date.modified2010-09-21T06:56:57Z
dc.identifier.issn1074-7427
dc.identifier.doi10.1016/j.nlm.2009.10.007
dc.identifier.urihttp://hdl.handle.net/10072/32211
dc.description.abstractMice can learn a food preference from odor cues transmitted on the breath of a conspecific, even if the "demonstrator" is anesthetized. To our knowledge there are no studies examining the effect of anesthetizing the "observer" on development of memory for socially transmitted food preferences (STFP). In Experiment 1 we found that 2-4 month-old F2 C57Bl/6x129sv male and female mice demonstrated a STFP after a 5 min exposure to an anesthetized demonstrator mouse when tested 24 h later. In Experiment 2, observer mice anesthetized with Sagatal (60 mg/kg) prior to the "social interaction" preferentially avoided the cued food when tested 24 h later. This aversion was not due to any overt aversive effects of this dose of Sagatal because mice that ate the food and were then anesthetized, or could only smell the food for 5 min while anesthetized, showed no preference or aversion. In a third experiment we found that the Sagatal-induced aversion was not a general property of anesthesia because there were varied results produced by observer mice treated with anesthetic drugs with different mechanisms of action. Vetalar (200 mg/kg) and Rompun (10 mg/kg) treated animals ate similar amounts of cued and non-cued food at test, indicating an absence of learning. Hypnorm (0.5 ml/kg) treated animals showed a preference for the cued food whereas those treated with Hypnovel (2.5 ml/kg) showed an aversion to the cued food. These results show that the food aversion observed with Sagatal is not a general property of anesthetic agents, but appears to be restricted to those acting primarily on the GABAergic system. Thus, we have shown that under certain conditions it is possible for an anesthetized observer mouse to learn a preference or aversion of a socially-linked olfactory cue.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom268
dc.relation.ispartofpageto274
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeurobiology of Learning and Memory
dc.relation.ispartofvolume93
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchSensory systems
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320907
dc.subject.fieldofresearchcode52
dc.titleEffects of anesthetic agents on socially transmitted olfactory memories in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorBurne, Thomas HJ.
gro.griffith.authorJohnston, Amy N.


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