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dc.contributor.authorBurne, Thomasen_US
dc.contributor.authorJohnston, Amyen_US
dc.contributor.authorWilkinson, L.en_US
dc.contributor.authorKendrick, K.en_US
dc.date.accessioned2017-04-24T11:45:13Z
dc.date.available2017-04-24T11:45:13Z
dc.date.issued2010en_US
dc.date.modified2010-09-21T06:56:57Z
dc.identifier.issn10747427en_US
dc.identifier.doi10.1016/j.nlm.2009.10.007en_AU
dc.identifier.urihttp://hdl.handle.net/10072/32211
dc.description.abstractMice can learn a food preference from odor cues transmitted on the breath of a conspecific, even if the "demonstrator" is anesthetized. To our knowledge there are no studies examining the effect of anesthetizing the "observer" on development of memory for socially transmitted food preferences (STFP). In Experiment 1 we found that 2-4 month-old F2 C57Bl/6x129sv male and female mice demonstrated a STFP after a 5 min exposure to an anesthetized demonstrator mouse when tested 24 h later. In Experiment 2, observer mice anesthetized with Sagatal (60 mg/kg) prior to the "social interaction" preferentially avoided the cued food when tested 24 h later. This aversion was not due to any overt aversive effects of this dose of Sagatal because mice that ate the food and were then anesthetized, or could only smell the food for 5 min while anesthetized, showed no preference or aversion. In a third experiment we found that the Sagatal-induced aversion was not a general property of anesthesia because there were varied results produced by observer mice treated with anesthetic drugs with different mechanisms of action. Vetalar (200 mg/kg) and Rompun (10 mg/kg) treated animals ate similar amounts of cued and non-cued food at test, indicating an absence of learning. Hypnorm (0.5 ml/kg) treated animals showed a preference for the cued food whereas those treated with Hypnovel (2.5 ml/kg) showed an aversion to the cued food. These results show that the food aversion observed with Sagatal is not a general property of anesthetic agents, but appears to be restricted to those acting primarily on the GABAergic system. Thus, we have shown that under certain conditions it is possible for an anesthetized observer mouse to learn a preference or aversion of a socially-linked olfactory cue.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom268en_US
dc.relation.ispartofpageto274en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalNeurobiology of Learning and Memoryen_US
dc.relation.ispartofvolume93en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchSensory Systemsen_US
dc.subject.fieldofresearchcode110906en_US
dc.titleEffects of anesthetic agents on socially transmitted olfactory memories in miceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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