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dc.contributor.authorMcGrath, John
dc.contributor.authorSaha, Sukanta
dc.contributor.authorWelham, Joy
dc.contributor.authorSaadi, Ossama
dc.contributor.authorMacCauley, Clare
dc.contributor.authorChant, David
dc.date.accessioned2018-01-11T03:55:13Z
dc.date.available2018-01-11T03:55:13Z
dc.date.issued2004
dc.date.modified2010-07-16T06:08:30Z
dc.identifier.issn17417015en_US
dc.identifier.doi10.1186/1741-7015-2-13en_US
dc.identifier.urihttp://hdl.handle.net/10072/32289
dc.description.abstractBackground: Understanding variations in the incidence of schizophrenia is a crucial step in unravelling the aetiology of this group of disorders. The aims of this review are to systematically identify studies related to the incidence of schizophrenia, to describe the key features of these studies, and to explore the distribution of rates derived from these studies. Methods: Studies with original data related to the incidence of schizophrenia (published 1965-2001) were identified via searching electronic databases, reviewing citations and writing to authors. These studies were divided into core studies, migrant studies, cohort studies and studies based on Other Special Groups. Betweenand within-study filters were applied in order to identify discrete rates. Cumulative plots of these rates were made and these distributions were compared when the underlying rates were sorted according to sex, urbanicity, migrant status and various ethodological features. Results: We identified 100 core studies, 24 migrant studies, 23 cohort studies and 14 studies based on Other Special Groups. These studies, which were drawn from 33 countries, generated a total of 1,458 rates. Based on discrete core data for persons (55 studies and 170 rates), the distribution of rates was asymmetric and had a median value (10%-90% quantile) of 15.2 (7.7-43.0) per 100,000. The distribution of rates was significantly higher in males compared to females; the male/female rate ratio median (10%-90% quantile) was 1.40 (0.9-2.4). Those studies conducted in urban versus mixed urban-rural catchment areas generated significantly higher rate distributions. The distribution of rates in migrants was significantly higher compared to native-born; the migrant/native-born rate ratio median (10%-90% quantile) was 4.6 (1.0-12.8). Apart from the finding that older studies reported higher rates, other study features were not associated with significantly different rate distributions (e.g. overall quality, methods related to case finding, diagnostic confirmation and criteria, the use of age-standardization and age range). Conclusions: There is a wealth of data available on the incidence of schizophrenia. The width and skew of the rate distribution, and the significant impact of sex, urbanicity and migrant status on these distributions, indicate substantial variations in the incidence of schizophrenia.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Central Ltd.en_US
dc.publisher.placeUKen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto22en_US
dc.relation.ispartofissue13en_US
dc.relation.ispartofjournalBMC Medicineen_US
dc.relation.ispartofvolume2en_US
dc.subject.fieldofresearchEpidemiologyen_US
dc.subject.fieldofresearchcode111706en_US
dc.titleA systematic review of the incidence of schizophrenia: The distribution of rates and the influence of sex, urbanicity, migrant status and methodologyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPublisheden_US
gro.rights.copyright© 2004 McGrath et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose. DOI:https://doi.org/10.1186/1741-7015-2-13en_US
gro.date.issued2004
gro.hasfulltextFull Text


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