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dc.contributor.authorKeech, Anthony
dc.contributor.authorSimes, John
dc.contributor.authorBarter, Philip
dc.contributor.authorBest, James
dc.contributor.authorScott, Russell
dc.contributor.authorTaskinen, Marja-Riitta
dc.contributor.authorHamilton-Craig, Ian
dc.contributor.authoret al.
dc.date.accessioned2018-07-31T04:21:27Z
dc.date.available2018-07-31T04:21:27Z
dc.date.issued2006
dc.identifier.issn0140-6736
dc.identifier.doi10.1016/S0140-6736(06)69594-9
dc.identifier.urihttp://hdl.handle.net/10072/32294
dc.description.abstractIn undertaking further analyses of the FIELD study,1 we recently detected that the reported effects of fenofibrate adjusted for on-study use of other lipid-lowering therapy are not time-dependent as was stated. The aim of the analysis was to account for the higher rate of use of other lipid-lowering therapy (mostly statins) during the study in the placebo group (average 17%) than in the fenofibrate group (average 8%). A programming mis-specification meant that this secondary analysis used drop-in to other lipid-lowering therapy as a fixed, rather than as a time-dependent, covariate in the Cox regression model. The net effect is that, for patients who started lipid-lowering treatment during the trial without a prior on-study event, all their trial experience from the date of randomisation was grouped separately in the analysis for the comparisons of fenofibrate versus placebo (fixed covariate model). In this sense, subsequent lipid-lowering therapy was modelled like a baseline covariate. By contrast, the time-dependent model groups only the patients' experience after drop-in separately in the analysis.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherThe Lancet Publishing Group
dc.publisher.placeLondon, UK
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1415
dc.relation.ispartofpageto1415
dc.relation.ispartofissue9545
dc.relation.ispartofjournalThe Lancet
dc.relation.ispartofvolume368
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode11
dc.titleCorrection to the FIELD study report
dc.typeJournal article
dc.type.descriptionC3 - Articles (Letter/ Note)
dc.type.codeC - Journal Articles
gro.date.issued2015-05-15T04:38:03Z
gro.hasfulltextNo Full Text
gro.griffith.authorHamilton-Craig, Ian


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