Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library
Author(s)
Davis, Rohan A
Innocenti, Alessio
Poulsen, Sally-Ann
Supuran, Claudiu T
Year published
2010
Metadata
Show full item recordAbstract
Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM.Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM.
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Journal Title
Bioorganic & Medicinal Chemistry
Volume
18
Subject
Medicinal and biomolecular chemistry
Biologically active molecules
Organic chemistry
Pharmacology and pharmaceutical sciences
Biochemistry and cell biology