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  • Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

    Author(s)
    Davis, Rohan A
    Innocenti, Alessio
    Poulsen, Sally-Ann
    Supuran, Claudiu T
    Griffith University Author(s)
    Poulsen, Sally-Ann
    Davis, Rohan A.
    Year published
    2010
    Metadata
    Show full item record
    Abstract
    Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM.Mass-directed isolation of the CH2Cl2/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal α-pyrone, 7′,8′-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7′,8′-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC50 of 2.8 μM.
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    Journal Title
    Bioorganic & Medicinal Chemistry
    Volume
    18
    DOI
    https://doi.org/10.1016/j.bmc.2009.11.021
    Subject
    Medicinal and biomolecular chemistry
    Biologically active molecules
    Organic chemistry
    Pharmacology and pharmaceutical sciences
    Biochemistry and cell biology
    Publication URI
    http://hdl.handle.net/10072/32371
    Collection
    • Journal articles

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