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  • Temporal expression of fibroblast growth factor receptors during primary ligament repair

    Author(s)
    Cool, SM
    Snyman, CP
    Nurcombe, V
    Forwood, M
    Griffith University Author(s)
    Forwood, Mark R.
    Year published
    2004
    Metadata
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    Abstract
    Following injury, it is inherently difficult to completely restore the biomechanical properties of ligaments. Relatively little is known about the cellular mechanisms controlling ligament healing. Numerous studies have implicated fibroblast growth factors (FGFs) as key molecules during the initiation of the cellular proliferation, differentiation, migration and matrix deposition that characterise wound healing. While current surgical emphasis concentrates on growth factor intervention, the role of their cognate receptors (FGFRs) has largely been overlooked. Following transection of the medial collateral ligament (MCL) in ...
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    Following injury, it is inherently difficult to completely restore the biomechanical properties of ligaments. Relatively little is known about the cellular mechanisms controlling ligament healing. Numerous studies have implicated fibroblast growth factors (FGFs) as key molecules during the initiation of the cellular proliferation, differentiation, migration and matrix deposition that characterise wound healing. While current surgical emphasis concentrates on growth factor intervention, the role of their cognate receptors (FGFRs) has largely been overlooked. Following transection of the medial collateral ligament (MCL) in rabbits, we examined FGFR expression over a 14-day healing period. Using semi-quantitative RT-PCR, we observed a significant upregulation in FGFR2 expression after 3 days. By 7 days post injury, FGFR2 expression fell to basal levels in line with those of FGFR1 and 3, both of which remained unaffected by surgical transection. These results demonstrate a role for FGFR2 in fibroblast and endothelial cell proliferation in damaged ligament, and suggest a window for FGF therapy.
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    Journal Title
    Knee Surgery Sports Traumatology Arthroscopy
    Volume
    12
    Issue
    5
    DOI
    https://doi.org/10.1007/s00167-003-0444-x
    Subject
    Clinical sciences
    Sports science and exercise
    Sports science and exercise not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/32433
    Collection
    • Journal articles

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