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dc.contributor.authorJ. Mearns, Freyaen_US
dc.contributor.authorL. S. Wong, Eliciaen_US
dc.contributor.authorShort, Kenen_US
dc.contributor.authorBrynn Hibbert, D.en_US
dc.contributor.authorJustin Gooding, J.en_US
dc.date.accessioned2017-05-03T15:40:06Z
dc.date.available2017-05-03T15:40:06Z
dc.date.issued2006en_US
dc.date.modified2010-07-20T21:56:46Z
dc.identifier.issn15214109en_US
dc.identifier.doi10.1002/elan.200603614en_AU
dc.identifier.urihttp://hdl.handle.net/10072/32461
dc.description.abstractHybridization-induced physical changes of DNA are exploited in the development of DNA switchable surfaces for electrochemical biosensing purposes. Two types of biosensing concepts are explored, both based on the same basic switchable surface. The interface is designed so that the end-tethered DNA is able to switch from a flexible state to a rigid one upon hybridization. The first biosensing concept described is a label-free system that uses air oxidation of the interface, followed by the change in accessibility of the surface upon hybridization to detect complementary target DNA. The second is a ferrocene-labeled system exploiting the change in DNA flexibility alone. Atomic force microscopy studies of the DNA switching surface are described.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWileyen_US
dc.publisher.placeWeinheim, Germanyen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1971en_US
dc.relation.ispartofpageto1981en_US
dc.relation.ispartofissue19-20en_US
dc.relation.ispartofjournalElectroanalysisen_US
dc.relation.ispartofvolume18en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchElectroanalytical Chemistryen_US
dc.subject.fieldofresearchSensor Technology (Chemical aspects)en_US
dc.subject.fieldofresearchcode030102en_US
dc.subject.fieldofresearchcode030107en_US
dc.titleDNA biosensor concepts based on a change in the DNA persistence length upon hybridizationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorMearns, Freya


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