Potential of Sodium Monofluoroacetate (1080) and Fluorocitrate to Bind to the Estrogen Receptor
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Sodium monofluoroacetate (1080), a vertebrate pesticide used in New Zealand, and its metabolite fluorocitrate, were tested to determine whether the pesticide could promote an estrogenic response by binding to a mammalian estrogen receptor (ER). ER preparations were isolated from sheep uterine tissue and used in a competitive binding assay. The assay was validated by generating displacement curves for the natural estrogen (E2) and known environmental estrogens like o,p'-DDT and 4-nonylphenol. The known estrogenic pesticide o,p'-DDT showed significant displacement of E2 while neither 1080 nor its active metabolite fluorocitrate had any effect on ER binding. Sodium monofluoroacetate and fluorocitrate are unlikely to promote estrogenic or anti-estrogenic effects by binding to the ER.
Australasian Journal of Ecotoxicology
Environmental Impact Assessment