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  • Effects of a phytosterol mixture on male fish plasma lipoprotein fractions and testis P450scc activity

    Author
    I. Gilman, Christine
    D.L. Leusch, Frederic
    Carl Breckenridge, W.
    L. MacLatchy, Deborah
    Year published
    2003
    Metadata
    Show full item record
    Abstract
    Plant sterols (phytosterols) have been identified as one potential source of reproductive effects in fish living downstream of pulp mills. ߭Sitosterol, the predominant plant sterol in pulp mill effluent, has previously been shown to decrease plasma sex steroid and cholesterol levels and in vitro gonadal steroid production in fish. In this study, male brook trout (Salvelinus fontinalis) and goldfish (Carassius auratus) were exposed to a phytosterol mixture (72% ߭sitosterol) via Silastic intraperitoneal implants to help elucidate the mechanisms of action of phytosterols on steroid depression. As cholesterol is exogenously ...
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    Plant sterols (phytosterols) have been identified as one potential source of reproductive effects in fish living downstream of pulp mills. ߭Sitosterol, the predominant plant sterol in pulp mill effluent, has previously been shown to decrease plasma sex steroid and cholesterol levels and in vitro gonadal steroid production in fish. In this study, male brook trout (Salvelinus fontinalis) and goldfish (Carassius auratus) were exposed to a phytosterol mixture (72% ߭sitosterol) via Silastic intraperitoneal implants to help elucidate the mechanisms of action of phytosterols on steroid depression. As cholesterol is exogenously supplied for gonadal steroidogenesis, changes in plasma cholesterol fractions were examined. In male brook trout, low-density lipoprotein cholesterol and triglyceride levels decreased significantly, 43 and 50%, respectively, in phytosterol-treated fish. It is improbable, however, that these decreases are linked to depressed gonadal steroidogenesis in fish. The activity of P450scc, which converts cholesterol to pregnenolone (the first step in the steroidogenic pathway), was not affected in testis mitochondria isolated from brook trout or goldfish. Further investigation of the mechanisms of action of phytosterols is required.
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    Journal Title
    General and Comparative Endocrinology
    Volume
    130
    Issue
    2
    DOI
    https://doi.org/10.1016/S0016-6480(02)00590-7
    Subject
    Clinical Sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/32491
    Collection
    • Journal articles

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