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dc.contributor.authorGilman, CI
dc.contributor.authorLeusch, FDL
dc.contributor.authorBreckenridge, WC
dc.contributor.authorMacLatchy, DL
dc.date.accessioned2017-05-03T13:55:15Z
dc.date.available2017-05-03T13:55:15Z
dc.date.issued2003
dc.date.modified2010-07-21T04:56:12Z
dc.identifier.issn0016-6480
dc.identifier.doi10.1016/S0016-6480(02)00590-7
dc.identifier.urihttp://hdl.handle.net/10072/32491
dc.description.abstractPlant sterols (phytosterols) have been identified as one potential source of reproductive effects in fish living downstream of pulp mills. ߭Sitosterol, the predominant plant sterol in pulp mill effluent, has previously been shown to decrease plasma sex steroid and cholesterol levels and in vitro gonadal steroid production in fish. In this study, male brook trout (Salvelinus fontinalis) and goldfish (Carassius auratus) were exposed to a phytosterol mixture (72% ߭sitosterol) via Silastic intraperitoneal implants to help elucidate the mechanisms of action of phytosterols on steroid depression. As cholesterol is exogenously supplied for gonadal steroidogenesis, changes in plasma cholesterol fractions were examined. In male brook trout, low-density lipoprotein cholesterol and triglyceride levels decreased significantly, 43 and 50%, respectively, in phytosterol-treated fish. It is improbable, however, that these decreases are linked to depressed gonadal steroidogenesis in fish. The activity of P450scc, which converts cholesterol to pregnenolone (the first step in the steroidogenic pathway), was not affected in testis mitochondria isolated from brook trout or goldfish. Further investigation of the mechanisms of action of phytosterols is required.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom172
dc.relation.ispartofpageto184
dc.relation.ispartofissue2
dc.relation.ispartofjournalGeneral and Comparative Endocrinology
dc.relation.ispartofvolume130
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3009
dc.subject.fieldofresearchcode320299
dc.titleEffects of a phytosterol mixture on male fish plasma lipoprotein fractions and testis P450scc activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorLeusch, Frederic


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