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dc.contributor.authorD. Swagell, Christopheren_US
dc.contributor.authorC. Henly, Debraen_US
dc.contributor.authorPhillip Morris, C.en_US
dc.date.accessioned2017-04-24T13:27:31Z
dc.date.available2017-04-24T13:27:31Z
dc.date.issued2005en_US
dc.date.modified2010-08-13T07:23:24Z
dc.identifier.issn0006291Xen_US
dc.identifier.doi10.1016/j.bbrc.2004.12.188en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33006
dc.description.abstractSaturated fat plays a role in common debilitating diseases such as obesity, type 2 diabetes, and coronary heart disease. It is also clear that certain fatty acids act as regulators of metabolism via both direct and indirect signalling of target tissues. As the molecular mechanisms of saturated fatty acid signalling in the liver are poorly defined, hepatic gene expression analysis was undertaken in a human hepatocyte cell line after incubation with palmitate. Profiling of mRNA expression using cDNA microarray analysis revealed that 162 of approximately 18,000 genes tested were differentially expressed after incubation with palmitate for 48 h. Altered transcription profiles were observed in a wide variety of genes, including genes involved in lipid and cholesterol transport, cholesterol catabolism, cell growth and proliferation, cell signalling, ߭oxidation, and oxidative stress response. While palmitate signalling has been examined in pancreatic ߭cells, this is the first report showing that palmitate regulates expression of numerous genes via direct molecular signalling mechanisms in liver cells.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAcademic Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom432en_US
dc.relation.ispartofpageto441en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalBiochemical and biophysical research communicationsen_US
dc.relation.ispartofvolume328en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030499en_US
dc.titleExpression analysis of a human hepatic cell line in response to palmitateen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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