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  • Alkaloids from roots of Stemona sessilifolia and their antitussive activities

    Author(s)
    Yang, Xin-Zhou
    Zhu, Jian-Yu
    Tang, Chun-Ping
    Ke, Chang-Qiang
    Lin, Ge
    Cheng, Tin-Yan
    A. Rudd, John
    Ye, Yang
    Griffith University Author(s)
    Yang, Xinzhou
    Year published
    2009
    Metadata
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    Abstract
    Protostemonamide (1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine (2), stemospironine (4), and maistemonine (7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine (11) had antitussive activity following i. c. v. administration.Protostemonamide (1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine (2), stemospironine (4), and maistemonine (7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine (11) had antitussive activity following i. c. v. administration.
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    Journal Title
    Planta Medica
    Volume
    75
    Issue
    2
    DOI
    https://doi.org/10.1055/s-0028-1088345
    Subject
    Pharmacology and Pharmaceutical Sciences not elsewhere classified
    Plant Biology
    Complementary and Alternative Medicine
    Pharmacology and Pharmaceutical Sciences
    Publication URI
    http://hdl.handle.net/10072/33015
    Collection
    • Journal articles

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