Bicyclononane aldehydes and antiproliferative constituents from amomum tsao-ko

Abstract

A racemic mixture of a new bicyclononane aldehyde, (1RS,5SR,6RS)-5 hydroxybicyclo[4.3.0]non-2-ene-2-carbaldehyde (1) was isolated from the fruits of Amomum tsao-ko, together with 12 known compounds (2-13). The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 1-13 was assessed in the murine neuroblastoma cell line N2a