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dc.contributor.authorHorton, R.en_US
dc.contributor.authorStuart, J.en_US
dc.contributor.authorChristensen, H.en_US
dc.contributor.authorBorrow, R.en_US
dc.contributor.authorGuthrie, T.en_US
dc.contributor.authorDavenport, V.en_US
dc.contributor.authorFinn, A.en_US
dc.contributor.authorteam, ALSPAC studyen_US
dc.contributor.authorWilliams, N.en_US
dc.contributor.authorHeyderman, R.en_US
dc.date.accessioned2017-05-03T15:35:07Z
dc.date.available2017-05-03T15:35:07Z
dc.date.issued2005en_US
dc.identifier.issn09502688en_US
dc.identifier.doi10.1017/S0950268805004097en_US
dc.identifier.urihttp://hdl.handle.net/10072/33105
dc.description.abstractAsymptomatic carriage of Neisseria meningitidis is common (5-35% of individuals) while the incidence of invasive meningococcal disease is fairly low (<1-5 per 100 000 per annum in Europe). Naturally acquired protective immunity may account for this difference. In this study, we investigated the relationship between anti-meningococcal salivary IgA and age and carriage. We showed that salivary IgA to a range of meningococcal antigens increased successively with age with some specificity for commonly circulating serosubtypes. In a group of 258 students 37 (14%) of whom were carriers of N. meningitidis serogroup B, higher levels of specific IgA were associated with carriage. Stratified analysis revealed a positive relationship between smoking and specific anti-N. meningitidis IgA independent of current carriage, weighted odds ratio (OR) 4.1 (95% CI 1.1-18) and OR 3.8 (95% CI 0.96-16) for reference strains B:1:P1.14 and B:4:P1.5,4 respectively. These data implicate IgA as a factor in host defence from meningococcal invasion, although the precise mechanisms remain uncertain.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherCambridge University Pressen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom883en_US
dc.relation.ispartofpageto889en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalEpidemiology and Infectionen_US
dc.relation.ispartofvolume133en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical Infection Agents (incl. Prions)en_US
dc.subject.fieldofresearchcode110802en_US
dc.titleInfluence of age and carriage status on salivary IgA to Neisseria meningitidisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-06-03T02:53:16Z
gro.hasfulltextNo Full Text


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