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dc.contributor.authorSirdaarta, J
dc.contributor.authorCock, IE
dc.contributor.editorElizabeth Williamson
dc.date.accessioned2017-05-03T11:29:02Z
dc.date.available2017-05-03T11:29:02Z
dc.date.issued2010
dc.date.modified2010-09-10T05:18:23Z
dc.identifier.issn0951-418X
dc.identifier.doi10.1002/ptr.2946
dc.identifier.urihttp://hdl.handle.net/10072/33143
dc.description.abstractThis study reports on the induction of oxidative stress in aerobic cell systems by Aloe barbadensis Miller (Aloe vera) juice using the salt water crustacean Artemia franciscana as a model. A consistent pattern was observed where Artemia franciscana nauplii responded to Aloe vera juice exposure with a decrease in the overall activity of redox related enzymes. Exposure of Artemia franciscana to sub-lethal levels of Aloe vera juice resulted in a decreased activity of thioredoxin reductase, glutathione reductase and glutathione peroxidase by 34% (66 % enzymatic activity), 79% (21 % enzymatic activity) and 90% (10 % enzymatic activity) respectively. Similarly apparent was the trend whereby the co-exposure of the nauplii to vitamin E counteracted this effect. For each of the biomarker enzymes tested, vitamin E co-exposure resulted in enzyme activities closer to the control value (78%, 56% and 32% of control enzymatic activities for thioredoxin reductase, glutathione reductase and glutathione peroxidase activity respectively). These results indicate that exposure to sub-lethal doses of Aloe vera juice induces alterations in the cellular redox status of Artemia franciscana and that vitamin E addition helps the Artemia franciscana nauplii to overcome/block the juice induced oxidative stress.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent107510 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons Ltd.
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom360
dc.relation.ispartofpageto364
dc.relation.ispartofissue3
dc.relation.ispartofjournalPhytotherapy Research
dc.relation.ispartofvolume24
dc.rights.retentionY
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleEffect of Aloe barbadensis Miller juice on oxidative stress biomarkers in aerobic cells using Artemia franciscana as a model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.rights.copyright© 2010 John Wiley & Sons, Ltd. This is the pre-peer reviewed version of the following article: Effect of Aloe barbadensis Miller juice on oxidative stress biomarkers in aerobic cells using Artemia franciscana as a model, Phytotherapy Research Volume 24, Issue 3, 2010, 360-364, which has been published in final form at 10.1002/ptr.2946.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorP, Joseph S.


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