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  • Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury

    Author(s)
    Kalincik, Tomas
    Choi, Eun A
    Feron, Francois
    Bianco, John
    Sutharsan, Ratneswary
    Hayward, Ian
    Mackay-Sim, Alan
    Carrive, Pascal
    Waite, Phil ME
    Griffith University Author(s)
    Mackay-Sim, Alan
    Year published
    2010
    Metadata
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    Abstract
    Autonomic dysreflexia is a common complication in high spinal cord injury and can result in serious consequences and death. Here we have examined the effect of acute transplantation of olfactory ensheathing cells on cardiovascular functions in rats. After T4 transection, radio-telemetric recording in conscious animals was used to study blood pressure and heart rate at rest and during autonomic dysreflexia for up to 8 weeks post-injury. Olfactory ensheathing cells from syngeneic rats were transplanted at the injury site; control animals received culture medium only. At the study end point, we examined morphometric features ...
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    Autonomic dysreflexia is a common complication in high spinal cord injury and can result in serious consequences and death. Here we have examined the effect of acute transplantation of olfactory ensheathing cells on cardiovascular functions in rats. After T4 transection, radio-telemetric recording in conscious animals was used to study blood pressure and heart rate at rest and during autonomic dysreflexia for up to 8 weeks post-injury. Olfactory ensheathing cells from syngeneic rats were transplanted at the injury site; control animals received culture medium only. At the study end point, we examined morphometric features of sympathetic preganglionic neurons above and below the injury. T4 transection resulted in a fall in resting mean arterial pressure and an increase in resting heart rate. Colorectal distension, used to trigger autonomic dysreflexia, caused episodic hypertension and bradycardia. Although the cell transplantation had no effect on resting cardiovascular parameters, it led to a significantly faster recovery from hypertension, with the recovery time shortened by approximately 25%. The transection resulted in an increase in soma size of sympathetic preganglionic neurons above and below the injury. OEC transplantation normalised this change below the injury and increased dendritic length of preganglionic neurons above the injury, compared to controls. It has been proposed that changes in sympathetic preganglionic neurons following spinal cord transection may be related to the development of autonomic dysreflexia. Our results suggest that olfactory ensheathing cells may alter the morphology of these neurons, and hence modify their activity in the neuronal networks responsible for the dysreflexic reaction.
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    Journal Title
    Autonomic Neuroscience: Basic and Clinical
    Volume
    154
    Issue
    1-2
    DOI
    https://doi.org/10.1016/j.autneu.2009.10.001
    Subject
    Clinical sciences
    Neurosciences
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/33148
    Collection
    • Journal articles

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