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dc.contributor.authorTang, Liangdanen_US
dc.contributor.authorYang, Junzhengen_US
dc.contributor.authorNg, Shu-Kayen_US
dc.contributor.authorRodriguez, Noahen_US
dc.contributor.authorChoi, Pui-Wahen_US
dc.contributor.authorVitonis, Allisonen_US
dc.contributor.authorWang, Kuien_US
dc.contributor.authorJ. McLachlan, Geoffreyen_US
dc.contributor.authorJ. Caiazzo Jr., Roberten_US
dc.contributor.authorC.-S. Liu, Brianen_US
dc.contributor.authorR. Welch, Williamen_US
dc.contributor.authorW. Cramer, Danielen_US
dc.contributor.authorS. Berkowitz, Rossen_US
dc.contributor.authorNg, Shu-Wingen_US
dc.date.accessioned2017-04-24T12:59:22Z
dc.date.available2017-04-24T12:59:22Z
dc.date.issued2010en_US
dc.date.modified2013-09-01T23:13:58Z
dc.identifier.issn0959-8049en_US
dc.identifier.doi10.1016/j.ejca.2009.10.003en_US
dc.identifier.urihttp://hdl.handle.net/10072/33154
dc.description.abstractMucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco exposure is a significant risk factor for developing mucinous ovarian cancer. Detection of autoantibody reactivity is useful in biomarker discovery and for explaining the role of important pathophysiologic pathways in disease. In order to study if there are specific antibody biomarkers in the plasma samples of mucinous ovarian cancer patients, we have initiated a screen by employing a 'reverse capture antibody microarray' platform that uses native host antigens derived from mucinous ovarian tissues as 'baits' for the capture of differentially labelled patient and control autoantibodies. Thirty-five autoantibodies that were significantly elevated in the cancer plasma samples compared with healthy controls, and six autoantibodies that segregated smoking and non-smoking patients were identified. Functional annotation of the antibody targets has identified nine target antigens involved in integrin and Wnt signalling pathways. Immunohistochemistry of archived ovarian specimens showed significant overexpression of eight of the nine target antigens in mucinous ovarian tumour tissues, suggesting that plasma autoantibodies from mucinous ovarian cancer patients might have heightened reactivities with epitopes presented by these overexpressed antigens. Autoantibody profiling may have an unexpected utility in uncovering key signalling pathways that are dysregulated in the system of interest.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent577079 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom170en_US
dc.relation.ispartofpageto179en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalEuropean Journal of Canceren_US
dc.relation.ispartofvolume46en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode230204en_US
dc.subject.fieldofresearchcode270201en_US
dc.titleAutoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian canceren_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2010 Wiley-Blackwell Publishing. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.The definitive version is available at www.interscience.wiley.comen_US
gro.date.issued2010
gro.hasfulltextFull Text


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