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dc.contributor.authorTang, Liangdan
dc.contributor.authorYang, Junzheng
dc.contributor.authorNg, Shu-Kay
dc.contributor.authorRodriguez, Noah
dc.contributor.authorChoi, Pui-Wah
dc.contributor.authorVitonis, Allison
dc.contributor.authorWang, Kui
dc.contributor.authorMcLachlan, Geoffrey J
dc.contributor.authorCaiazzo, Robert J
dc.contributor.authorLiu, Brian C-S
dc.contributor.authorWelch, William R
dc.contributor.authorCramer, Daniel W
dc.contributor.authorBerkowitz, Ross S
dc.contributor.authorNg, Shu-Wing
dc.date.accessioned2017-05-03T15:26:15Z
dc.date.available2017-05-03T15:26:15Z
dc.date.issued2010
dc.date.modified2013-09-01T23:13:58Z
dc.identifier.issn0959-8049
dc.identifier.doi10.1016/j.ejca.2009.10.003
dc.identifier.urihttp://hdl.handle.net/10072/33154
dc.description.abstractMucinous epithelial ovarian cancers are clinically and morphologically distinct from the other histopathologic subtypes of ovarian cancer. Unlike other ovarian subtypes, epidemiologic studies have indicated that tobacco exposure is a significant risk factor for developing mucinous ovarian cancer. Detection of autoantibody reactivity is useful in biomarker discovery and for explaining the role of important pathophysiologic pathways in disease. In order to study if there are specific antibody biomarkers in the plasma samples of mucinous ovarian cancer patients, we have initiated a screen by employing a 'reverse capture antibody microarray' platform that uses native host antigens derived from mucinous ovarian tissues as 'baits' for the capture of differentially labelled patient and control autoantibodies. Thirty-five autoantibodies that were significantly elevated in the cancer plasma samples compared with healthy controls, and six autoantibodies that segregated smoking and non-smoking patients were identified. Functional annotation of the antibody targets has identified nine target antigens involved in integrin and Wnt signalling pathways. Immunohistochemistry of archived ovarian specimens showed significant overexpression of eight of the nine target antigens in mucinous ovarian tumour tissues, suggesting that plasma autoantibodies from mucinous ovarian cancer patients might have heightened reactivities with epitopes presented by these overexpressed antigens. Autoantibody profiling may have an unexpected utility in uncovering key signalling pathways that are dysregulated in the system of interest.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent577079 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom170
dc.relation.ispartofpageto179
dc.relation.ispartofissue1
dc.relation.ispartofjournalEuropean Journal of Cancer
dc.relation.ispartofvolume46
dc.rights.retentionY
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1117
dc.titleAutoantibody profiling to identify biomarkers of key pathogenic pathways in mucinous ovarian cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2010 Wiley-Blackwell Publishing. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher.The definitive version is available at www.interscience.wiley.com
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorNg, Shu Kay Angus


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