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dc.contributor.authorPowell, Katieen_US
dc.contributor.authorKelly, Paulineen_US
dc.contributor.authorMcDonnell, Annen_US
dc.contributor.authorLaakso, Liisaen_US
dc.contributor.authorRalph, Stephenen_US
dc.date.accessioned2017-05-03T12:57:50Z
dc.date.available2017-05-03T12:57:50Z
dc.date.issued2010en_US
dc.date.modified2010-09-01T08:08:18Z
dc.identifier.issn15495418en_US
dc.identifier.doi10.1089/pho.2008.2445en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33163
dc.description.abstractObjective: This study compared the effects of different doses (J/cm2) of laser phototherapy at wavelengths of either 780, 830, or 904nm on human breast carcinoma, melanoma, and immortalized human mammary epithelial cell lines in vitro. In addition, we examined whether laser irradiation would malignantly transform the murine fibroblast NIH3T3 cell line. Background: Laser phototherapy is used in the clinical treatment of breast cancer-related lymphoedema, despite limited safety information. This study contributes to systematically developing guidelines for the safe use of laser in breast cancer-related lymphoedema. Methods: Human breast adenocarcinoma (MCF-7), human breast ductal carcinoma with melanomic genotypic traits (MDA-MB-435S), and immortalized human mammary epithelial (SVCT and Bre80hTERT) cell lines were irradiated with a single exposure of laser. MCF-7 cells were further irradiated with two and three exposures of each laser wavelength. Cell proliferation was assessed 24h after irradiation. Results: Although certain doses of laser increased MCF-7 cell proliferation, multiple exposures had either no effect or showed negative dose response relationships. No sign of malignant transformation of cells by laser phototherapy was detected under the conditions applied here. Conclusion: Before a definitive conclusion can be made regarding the safety of laser for breast cancer-related lymphoedema, further in vivo research is required.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherMary Ann Liebert, Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom115en_US
dc.relation.ispartofpageto123en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalPhotomedicine and Laser Surgeryen_US
dc.relation.ispartofvolume28en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleThe Effect of Laser Irradiation on Proliferation of Human Breast Carcinoma, Melanoma and Immortalized Mammary Epithelial Cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2010 Mary Ann Liebert, Inc., publishers. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.en_AU
gro.date.issued2010
gro.hasfulltextNo Full Text


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