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dc.contributor.authorA. Ruhayel, Rashaen_US
dc.contributor.authorJ. Berners-Price, Susanen_US
dc.date.accessioned2017-05-03T15:42:33Z
dc.date.available2017-05-03T15:42:33Z
dc.date.issued2010en_US
dc.date.modified2010-09-29T06:54:12Z
dc.identifier.issn00219584en_US
dc.identifier.doi10.1021/ed100271hen_AU
dc.identifier.urihttp://hdl.handle.net/10072/33186
dc.description.abstractNuclear magnetic resonance (NMR) spectroscopy is an indispensable tool used for the elucidation and confirmation of the solution structure of molecules that was first reported in 1938 by Isidor Rabi (1). A mere eight years later, its use was adapted for structure elucidation of liquids and solids by Felix Bloch and Edward Mills Purcell (2, 3), who four years later shared a Nobel Prize for their work. In more recent times, NMR spectroscopy has been extended to the study of larger biomolecules and has become a technique of paramount importance. In order to introduce students to this field of study, it is imperative that there be a sound understanding of how this technique works. Veeraraghavan describes a short course that effectively introduces students to the basics of NMR spectroscopy (4). A review of the articles available through this Journal shows examples of NMR studies of biological molecules such as peptides, phospholipids, and cytochrome c (5-8); however, there are no examples that use NMR spectroscopy to investigate DNA structure. The work herein represents a 6-h laboratory workshop with the aim of confirming the 3D structure of a short doublestrand DNA sequence, achieved using 2D 1H NOESY NMR spectroscopy, with the aid of a computer-generated model.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAmerican Chemical Societyen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom732en_US
dc.relation.ispartofpageto734en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalJournal of Chemical Educationen_US
dc.relation.ispartofvolume87en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchBioinorganic Chemistryen_US
dc.subject.fieldofresearchcode030201en_US
dc.titleConfirming the 3D Solution Structure of a Short Double-Stranded DNA Sequence Using NMR Spectroscopyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2010 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_AU
gro.date.issued2010
gro.hasfulltextNo Full Text


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