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dc.contributor.authorUlett, Glen C
dc.contributor.authorWebb, Richard I
dc.contributor.authorUlett, Kimberly B
dc.contributor.authorCui, Xiangqin
dc.contributor.authorBenjamin, William H
dc.contributor.authorCrowley, Michael
dc.contributor.authorSchembri, Mark A
dc.date.accessioned2017-05-03T15:29:32Z
dc.date.available2017-05-03T15:29:32Z
dc.date.issued2010
dc.identifier.issn0022-1899
dc.identifier.doi10.1086/650696
dc.identifier.urihttp://hdl.handle.net/10072/33208
dc.description.abstractGroup B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlying GBS urinary tract infections are unknown. We investigated whether uropathogenic GBS can bind to bladder uroepithelium to initiate urinary tract infection. Uropathogenic GBS isolated from a patient with acute cystitis bound to human T24 bladder uroepithelial cells in close association with F-actin in statistically significantly higher numbers compared with nonuropathogenic GBS. In vivo modeling using transurethrally infected mice revealed superior fitness of uropathogenic GBS for bladder colonization and potent uropathogenic GBS-specific up-regulation of interleukin 1alpha during infection. Thus, binding of uropathogenic GBS to uroepithelium and vigorous induction of interleukin 1alpha represents the initial stages of GBS urinary tract infection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent455858 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherUniversity of Chicago Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom866
dc.relation.ispartofpageto870
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Infectious Diseases
dc.relation.ispartofvolume201
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical bacteriology
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320701
dc.titleGroup B Streptococcus (GBS) Urinary Tract Infection Involves Binding of GBS to Bladder Uroepithelium and Potent but GBS-Specific Induction of Interleukin 1α
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.rights.copyright© 2010 by University of Chicago Press. The attached file is reproduced here in accordance with the copyright policy of the publisher. First published in the Journal of Infectious Diseases with publishing partner, Infectious Diseases Society of America. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-05-31T22:17:53Z
gro.hasfulltextFull Text
gro.griffith.authorUlett, Glen C.


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