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  • Potential of Sodium Fluoroacetate (1080) and Fluorocitrate to Bind to Androgen and Oestrogen Recept ors

    Author(s)
    Tremblay, Louis
    Fisher, Penny
    Leusch, Fred
    van den Heuvel, Michael
    Nicolas, Jean-Claude
    Pillon, Arnaud
    Balaguer, Patrick
    Griffith University Author(s)
    Leusch, Frederic
    Year published
    2005
    Metadata
    Show full item record
    Abstract
    Sodium fl uoroacetate (1080) is a vertebrate pesticide used for controlling fi eld populations of introduced pest mammals in New Zealand and Australia especially. There have been scientifi c and public concerns over the potential for adverse environmental effects of 1080 use. To address one recent concern, an investigation of the potential endocrine-disrupting effects of 1080 and its active metabolite fl uorocitrate was conducted using in vitro assays. Binding of 1080 and fl uorocitrate to rainbow trout brain and human androgen (AR) and alpha oestrogen receptors (ER) was assessed. Neither 1080 nor fl uorocitrate had any ...
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    Sodium fl uoroacetate (1080) is a vertebrate pesticide used for controlling fi eld populations of introduced pest mammals in New Zealand and Australia especially. There have been scientifi c and public concerns over the potential for adverse environmental effects of 1080 use. To address one recent concern, an investigation of the potential endocrine-disrupting effects of 1080 and its active metabolite fl uorocitrate was conducted using in vitro assays. Binding of 1080 and fl uorocitrate to rainbow trout brain and human androgen (AR) and alpha oestrogen receptors (ER) was assessed. Neither 1080 nor fl uorocitrate had any effect on ER or AR binding with any of the bioassays employed. Accordingly, 1080 and fl uorocitrate are considered unlikely to promote androgenic, anti-androgenic, oestrogenic or anti-oestrogenic effects by binding to the ER or AR.
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    Journal Title
    Australasian Journal of Ecotoxicology
    Volume
    11
    Issue
    3
    Publisher URI
    http://www.ecotox.org.au/aje.html
    Note
    Published title contains space in "receptors"
    Subject
    Environmental Impact Assessment
    Chemical Sciences
    Environmental Sciences
    Biological Sciences
    Publication URI
    http://hdl.handle.net/10072/33214
    Collection
    • Journal articles

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