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dc.contributor.authorMcManus, Donald P
dc.contributor.authorGray, Darren J
dc.contributor.authorLi, Yuesheng
dc.contributor.authorFeng, Zheng
dc.contributor.authorWilliams, Gail M
dc.contributor.authorStewart, Donald
dc.contributor.authorRey-Ladino, Jose
dc.contributor.authorRoss, Allen G
dc.date.accessioned2017-09-27T02:50:47Z
dc.date.available2017-09-27T02:50:47Z
dc.date.issued2010
dc.date.modified2010-08-04T02:38:11Z
dc.identifier.issn0893-8512
dc.identifier.doi10.1128/CMR.00044-09
dc.identifier.urihttp://hdl.handle.net/10072/33244
dc.description.abstractSummary: The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in China has invoked considerable global concern. The TGD will result in changes in the water level and silt deposition downstream, favoring the reproduction of Oncomelania snails. Combined with blockages of the Yangtze River's tributaries, these changes will increase the schistosomiasis transmission season within the marshlands along the middle and lower reaches of the Yangtze River. The changing schistosome transmission dynamics necessitate a comprehensive strategy to control schistosomiasis. This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. Drug delivery requires a substantial infrastructure to regularly cover all parts of an area of endemicity. This makes chemotherapy expensive and, as compliance is often low, a less than satisfactory control option. There is increasing disquiet about the possibility that PZQ-resistant schistosomes will develop. Consequently, as mathematical modeling predicts, vaccine strategies represent an essential component in the future control of schistosomiasis in China. With the inclusion of focal mollusciciding, improvements in sanitation, and health education into the control scenario, China's target of reducing the level of schistosome infection to less than 1% by 2015 may be achievable.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom442
dc.relation.ispartofpageto466
dc.relation.ispartofissue2
dc.relation.ispartofjournalClinical Microbiology Reviews
dc.relation.ispartofvolume23
dc.rights.retentionY
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320704
dc.subject.fieldofresearchcode3207
dc.titleSchistosomiasis in the People's Republic of China: The era of the Three Gorges Dam
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, Griffith University Medical Research College
gro.rights.copyright© 2010 American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorStewart, Donald E.
gro.griffith.authorRoss, Allen G.


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