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dc.contributor.authorBeattie, Karrenen_US
dc.contributor.authorRouf, Razinaen_US
dc.contributor.authorGander, Louisaen_US
dc.contributor.authorW. May, Tomen_US
dc.contributor.authorRatkowsky, Daviden_US
dc.contributor.authorD. Donner, Christopheren_US
dc.contributor.authorGill, Melvynen_US
dc.contributor.authorGrice, Darrenen_US
dc.contributor.authorTiralongo, Evelinen_US
dc.date.accessioned2017-04-24T11:53:49Z
dc.date.available2017-04-24T11:53:49Z
dc.date.issued2010en_US
dc.date.modified2010-08-04T02:38:13Z
dc.identifier.issn00319422en_US
dc.identifier.doi10.1016/j.phytochem.2010.03.016en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33245
dc.description.abstractIn this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybe canaria]2, C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC50 values of less-than-or-equals, slant0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC50 less-than-or-equals, slant 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC50 0.7-12 姯mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC50 1.5 and 2.0 姯mL, respectively).en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom948en_US
dc.relation.ispartofpageto955en_US
dc.relation.ispartofissue8-9en_US
dc.relation.ispartofjournalPhytochemistryen_US
dc.relation.ispartofvolume71en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classifieden_US
dc.subject.fieldofresearchcode110499en_US
dc.titleAntibacterial Metabolites from Australian Macrofungi from the Genus Cortinariusen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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