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dc.contributor.authorGopalan, Vinoden_US
dc.contributor.authorSmith, Roberten_US
dc.contributor.authorR. Nassiri, Mohammaden_US
dc.contributor.authorYasuda, Koichien_US
dc.contributor.authorAriana, Arminen_US
dc.contributor.authorY. Kim, Sangen_US
dc.contributor.authorHo, Yik-Hongen_US
dc.contributor.authorWeinstein, Stephenen_US
dc.contributor.authorC.-O. Tang, Johnnyen_US
dc.contributor.authorLam, Alfreden_US
dc.contributor.editorRicardo V Lloyden_US
dc.date.accessioned2017-05-03T15:15:55Z
dc.date.available2017-05-03T15:15:55Z
dc.date.issued2010en_US
dc.date.modified2010-10-20T07:01:02Z
dc.identifier.issn00468177en_US
dc.identifier.doi10.1016/j.humpath.2009.11.014en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33277
dc.description.abstractGAEC1 is a novel gene located at 7q22.1 that was detected in our previous work in esophageal cancer. The aims of the present study are to identify the copy number of GAEC1 in different colorectal tissues including carcinomas, adenomas, and nonneoplastic tissues and characterize any links to pathologic factors. The copy number of GAEC1 was studied by evaluating the quantitative amplification of GAEC1 DNA in 259 colorectal tissues (144 adenocarcinomas, 31 adenomas, and 84 nonneoplastic tissues) using real-time polymerase chain reaction. Copy number of GAEC1 DNA in colorectal adenocarcinomas was higher in comparison with nonneoplastic colorectum. Seventy-nine percent of the colorectal adenocarcinomas showed amplification and 15% showed deletion of GAEC1 (P < .0001). Of the adenomas, 90% showed deletion of GAEC1, with the remaining 10% showing normal copy number. The differences in GAEC1 copy number between colorectal adenocarcinoma, colorectal adenoma, and nonneoplastic colorectal tissue are significant (P < .0001). GAEC1 copy number was significantly higher in adenocarcinomas located in distal colorectum compared with proximal colon (P = .03). In conclusion, GAEC1 copy number was significantly different between colorectal adenocarcinomas, adenomas, and nonneoplastic colorectal tissues. The copy number was also related to the site of the cancer. These findings along with previous work in esophageal cancer imply that GAEC1 is commonly involved in the pathogenesis of colorectal adenocarcinoma. Copyright 2010 Elsevier Inc. All rights reserved.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent143375 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherW.B. Saunders & Co.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1009en_US
dc.relation.ispartofpageto1015en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalHuman Pathologyen_US
dc.relation.ispartofvolume41en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchPathologyen_US
dc.subject.fieldofresearchcode110316en_US
dc.titleGAEC1 and colorectal cancer: a study of the relationships between a novel oncogene and clinicopathologic featuresen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medicineen_US
gro.rights.copyrightCopyright 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2010
gro.hasfulltextFull Text


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