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dc.contributor.authorZhang, W
dc.contributor.authorRoss, AG
dc.contributor.authorMcManus, DP
dc.date.accessioned2017-05-11T12:31:04Z
dc.date.available2017-05-11T12:31:04Z
dc.date.issued2008
dc.date.modified2011-10-18T07:24:48Z
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/10072/33421
dc.description.abstractThe Echinococcus organisms, the cause of echinococcosis (hydatid disease), are parasitic helminths with life cycles involving a carnivorous definitive host (usually dog or fox) and an intermediate host (human, ungulate, or rodent). They are complex multicellular pathogens that, despite being under constant barrage by the immune system, are able to modulate antiparasite immune responses and persist and flourish in their mammalian hosts. Understanding how the immune system deals with these parasites is a major challenge. Recent application of modern molecular and immunological approaches has revealed insights on the nature of immune responses generated during the course of hydatid infection, although many aspects of the Echinococcus-host interplay remain unexplored. This review summarizes current understanding of the immunology of echinococcosis, indicates areas where information is lacking, and shows how knowledge of host protective immunity has been translated into the design and development of anti-Echinococcus vaccines for application in intermediate hosts.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association of Immunologists
dc.publisher.placeUSA
dc.publisher.urihttp://www.jimmunol.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom6679
dc.relation.ispartofpageto6685
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Immunology
dc.relation.ispartofvolume181
dc.rights.retentionY
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode1107
dc.titleMechanisms of Immunity in Hydatid Disease: Implications for Vaccine Development
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
gro.date.issued2008
gro.hasfulltextNo Full Text
gro.griffith.authorRoss, Allen G.


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