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dc.contributor.authorVickers, D
dc.contributor.authorRoss, AG
dc.contributor.authorMainar-Jaime, RC
dc.contributor.authorNeudorf, C
dc.contributor.authorShah, S
dc.date.accessioned2017-05-03T15:52:26Z
dc.date.available2017-05-03T15:52:26Z
dc.date.issued2006
dc.date.modified2010-08-13T07:25:03Z
dc.identifier.issn0820-3946
dc.identifier.doi10.1503/cmaj.051637
dc.identifier.urihttp://hdl.handle.net/10072/33443
dc.description.abstractBackground The transition from a whole-cell to a 5-component acellular pertussis vaccine provided a unique opportunity to compare the effect that each type of vaccine had on the incidence of pertussis, under routine conditions, among children less than 10 years of age. Methods Analyses were based on passive surveillance data collected between 1995 and 2005. The incidence of pertussis by year and birth cohort was compiled according to age during the surveillance period. We determined the association between vaccine type (whole-cell, acellular or a combination of both) and the incidence of pertussis using Poisson regression analysis after controlling for age (< 1 year, 1-4 years and 5-9 years) and vaccination history (i.e., partial or complete). Results During 7 of the 11 years surveyed, infants (< 1 year of age) had the highest incidence of pertussis. Among children born after 1997, when acellular vaccines were introduced, the rates of pertussis were highest among infants and preschool children (1-4 years of age). Poisson regression analysis revealed that, in the group given either the whole-cell vaccine or a combination of both vaccines, the incidence of pertussis was lower among infants and preschool children than among school-aged children (5-9 years). The reverse was true in the group given only an acellular vaccine, with a higher incidence among infants and preschool children than among school-aged children. Interpretation These results suggest that current immunization practices may not be adequate in protecting infants and children less than 5 years of age against pertussis. Altering available acellular formulations or adopting immunization practices used in some European countries may increase the clinical effectiveness of routine pertussis vaccination programs among infants and preschool children.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCanadian Medical Association
dc.publisher.placeCanada
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1213
dc.relation.ispartofpageto1217
dc.relation.ispartofissue10
dc.relation.ispartofjournalCanadian Medical Association Journal (CMAJ)
dc.relation.ispartofvolume175
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode32
dc.titleWhole-cell and acellular pertussis vaccination programs and rates of pertussis among infants and young children
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorRoss, Allen G.


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