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dc.contributor.authorMurrell, Melanie
dc.contributor.authorKhachigian, Levon
dc.contributor.authorWard, Michael R.
dc.date.accessioned2017-05-03T15:18:10Z
dc.date.available2017-05-03T15:18:10Z
dc.date.issued2007
dc.date.modified2010-08-16T06:49:09Z
dc.identifier.issn00219150
dc.identifier.doi10.1016/j.atherosclerosis.2006.11.016
dc.identifier.urihttp://hdl.handle.net/10072/33484
dc.description.abstractRestenosis after balloon angioplasty and stenting is exacerbated by low flow. Flow-dependent restenosis after angioplasty but not stenting is prevented by the antioxidant pyrrolidine dithiocarbamate (PDTC). c-jun may play a role in these events as AP-1 activity is both flow and redox sensitive. Carotid arteries of cholesterol fed rabbits underwent stenting or balloon injury in the presence of low or normal flow. c-jun mRNA expression was enhanced by low flow and injury (stent > balloon) and inhibited by the antioxidant PDTC irrespective of the injury type. The effect of locally delivered DZ13 (a DNAzyme specific for c-jun) or scrambled DZ13 (inactive DNAzyme) was assessed by histomorphometry at 28 days. Low flow significantly increased intimal hyperplasia in B and S relative to normal flow (P < 0.05). The active DNAzyme DZ13 markedly reduced intimal hyperplasia (P < 0.001) and increased lumen size (P < 0.05) in balloon-injured but not in stented segments, and abrogated the effect of low flow on restenosis after angioplasty, similar to the morphological effects of PDTC. We conclude that c-jun expression is enhanced by low flow and by injury (stent > balloon) and markedly attenuated by PDTC, and that c-jun is an important mediator of flow-dependent restenosis in balloon-injured but not stented vessels.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom364
dc.relation.ispartofpageto371
dc.relation.ispartofissue2
dc.relation.ispartofjournalAtherosclerosis
dc.relation.ispartofvolume194
dc.rights.retentionY
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1102
dc.subject.fieldofresearchcode1103
dc.titleThe role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2007
gro.hasfulltextNo Full Text
gro.griffith.authorMurrell, Melanie J.


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