dc.contributor.author | Murrell, Melanie | |
dc.contributor.author | Khachigian, Levon | |
dc.contributor.author | Ward, Michael R. | |
dc.date.accessioned | 2017-05-03T15:18:10Z | |
dc.date.available | 2017-05-03T15:18:10Z | |
dc.date.issued | 2007 | |
dc.date.modified | 2010-08-16T06:49:09Z | |
dc.identifier.issn | 00219150 | |
dc.identifier.doi | 10.1016/j.atherosclerosis.2006.11.016 | |
dc.identifier.uri | http://hdl.handle.net/10072/33484 | |
dc.description.abstract | Restenosis after balloon angioplasty and stenting is exacerbated by low flow. Flow-dependent restenosis after angioplasty but not stenting is prevented by the antioxidant pyrrolidine dithiocarbamate (PDTC). c-jun may play a role in these events as AP-1 activity is both flow and redox sensitive. Carotid arteries of cholesterol fed rabbits underwent stenting or balloon injury in the presence of low or normal flow. c-jun mRNA expression was enhanced by low flow and injury (stent > balloon) and inhibited by the antioxidant PDTC irrespective of the injury type. The effect of locally delivered DZ13 (a DNAzyme specific for c-jun) or scrambled DZ13 (inactive DNAzyme) was assessed by histomorphometry at 28 days. Low flow significantly increased intimal hyperplasia in B and S relative to normal flow (P < 0.05). The active DNAzyme DZ13 markedly reduced intimal hyperplasia (P < 0.001) and increased lumen size (P < 0.05) in balloon-injured but not in stented segments, and abrogated the effect of low flow on restenosis after angioplasty, similar to the morphological effects of PDTC. We conclude that c-jun expression is enhanced by low flow and by injury (stent > balloon) and markedly attenuated by PDTC, and that c-jun is an important mediator of flow-dependent restenosis in balloon-injured but not stented vessels. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | Ireland | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 364 | |
dc.relation.ispartofpageto | 371 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Atherosclerosis | |
dc.relation.ispartofvolume | 194 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Clinical Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Cardiorespiratory Medicine and Haematology | |
dc.subject.fieldofresearch | Clinical Sciences | |
dc.subject.fieldofresearchcode | 110399 | |
dc.subject.fieldofresearchcode | 1102 | |
dc.subject.fieldofresearchcode | 1103 | |
dc.title | The role of c-jun in PDTC-sensitive flow-dependent restenosis after angioplasty and stenting | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.date.issued | 2007 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Murrell, Melanie J. | |