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dc.contributor.authorHerrero, Lara
dc.contributor.authorTaylor, Adam
dc.contributor.authorRoques, Pierre
dc.contributor.authorLidbury, Brett A.
dc.contributor.authorMahalingam, Suresh
dc.contributor.editorS. Mahalingam, L. Herrero and B. Herring
dc.description.abstractAnimal models that reflect key aspects of human disease are invaluable tools for understanding the mechanisms of disease pathogenesis and development of treatment strategies. In particular, animal models play important roles in expanding the current understanding of the pathobiology of alphavirus infection. Alphaviruses are arthropod-borne viruses that are able to infect a variety of vertebrate hosts. In humans, infection can result in extensive morbidity and mortality. As the global distribution of alphaviruses expands, with recent outbreaks in new areas of the world, there is an overwhelming need to improve our understanding of alphavirus pathogenesis with the key objective of anti-alphaviral drug design. This chapter focuses on the application of alphaviral animal models with particular emphasis on how these models have expanded the understanding of disease mechanisms and have provided a foundation for the development of new treatments.en_US
dc.publisherCaister Academic Pressen_US
dc.publisher.placeUnited KIngdomen_US
dc.relation.ispartofbooktitleAlphaviruses: Current Biologyen_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.titleAnimal Models of Alphavirus-induced Inflammatory Diseaseen_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.hasfulltextNo Full Text

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