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dc.contributor.authorLiang, Liuen
dc.contributor.authorCare, Andrew
dc.contributor.authorZhang, Run
dc.contributor.authorLu, Yiqing
dc.contributor.authorPacker, Nicolle H.
dc.contributor.authorSunna, Anwar
dc.contributor.authorQian, Yi
dc.contributor.authorZvyagin, Andrei V.
dc.date.accessioned2017-05-11T01:21:34Z
dc.date.available2017-05-11T01:21:34Z
dc.date.issued2016
dc.identifier.issn1944-8244
dc.identifier.doi10.1021/acsami.6b00713
dc.identifier.urihttp://hdl.handle.net/10072/336511
dc.description.abstractThe treatment depth of existing photodynamic therapy (PDT) is limited because of the absorption of visible excitation light in biological tissue. It can be augmented by means of upconversion nanoparticles (UCNPs) transforming deep-penetrating near-infrared (NIR) light to visible light, exciting PDT drugs. We report here a facile strategy to assemble such PDT nanocomposites functionalized for cancer targeting, based on coating of the UCNPs with a silica layer encapsulating the Rose Bengal photosensitizer and bioconjugation to antibodies through a bifunctional fusion protein consisting of a solid-binding peptide linker genetically fused to Streptococcus Protein G′. The fusion protein (Linker-Protein G) mediates the functionalization of silica-coated UCNPs with cancer cell antibodies, allowing for specific target recognition and delivery. The resulting nanocomposites were shown to target cancer cells specifically, generate intracellular reactive oxygen species under 980 nm excitation, and induce NIR-triggered phototoxicity to suppress cancer cell growth in vitro.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom11945
dc.relation.ispartofpageto11953
dc.relation.ispartofissue19
dc.relation.ispartofjournalACS Applied Materials and Interfaces
dc.relation.ispartofvolume8
dc.subject.fieldofresearchMacromolecular and Materials Chemistry not elsewhere classified
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode030399
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode09
dc.titleFacile Assembly of Functional Upconversion Nanoparticles for Targeted Cancer Imaging and Photodynamic Therapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorPacker, Nicki


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