Show simple item record

dc.contributor.authorChristiansen, Maja N.
dc.contributor.authorChik, Jenny
dc.contributor.authorLee, Ling
dc.contributor.authorAnugraham, Merrina
dc.contributor.authorAbrahams, Jodie L.
dc.contributor.authorPacker, Nicolle H.
dc.date.accessioned2017-05-11T03:05:40Z
dc.date.available2017-05-11T03:05:40Z
dc.date.issued2014
dc.identifier.issn1615-9853
dc.identifier.doi10.1002/pmic.201300387
dc.identifier.urihttp://hdl.handle.net/10072/336528
dc.description.abstractGlycosylation of proteins is one of the most important PTMs, with more than half of all human proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has been implicated in many different diseases due to changes associated with biological function and protein folding. In cancer, there is increasing evidence pertaining to the role of glycosylation in tumour formation and metastasis. Alterations in cell surface glycosylation, particularly terminal motifs, can promote invasive behaviour of tumour cells that ultimately lead to the progression of cancer. While a majority of studies have investigated protein glycosylation changes in cancer cell lines and tumour tissue for individual cancers, the review presented here represents a comprehensive, in-depth overview of literature on the structural changes of glycosylation and their associated synthetic enzymes in five different cancer types originating from the breast, colon, liver, skin and ovary. More importantly, this review focuses on key similarities and differences between these cancers that reflect the importance of structural changes of cell surface N- and O-glycans, such as sialylation, fucosylation, degree of branching and the expression of specific glycosyltransferases for each cancer. It is envisioned that the understanding of these biologically relevant glycan alterations on cellular proteins will facilitate the discovery of novel glycan-based biomarkers which could potentially serve as diagnostic and prognostic indicators of cancer.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.ispartofpagefrom525
dc.relation.ispartofpageto546
dc.relation.ispartofissue4-5
dc.relation.ispartofjournalProteomics
dc.relation.ispartofvolume14
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchInformation and Computing Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode08
dc.subject.fieldofresearchcode11
dc.titleCell surface protein glycosylation in cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorAbrahams, Jodie L.
gro.griffith.authorPacker, Nicki


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record