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  • A mathematical model for atherosclerotic plaque formation and arterial wall remodelling

    Author(s)
    Islam, Md. Hamidul
    Johnston, Peter
    Griffith University Author(s)
    Johnston, Peter R.
    Islam, Md. Hamidul H.
    Year published
    2016
    Metadata
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    Abstract
    Atherosclerosis is a condition whereby fatty material is deposited in the walls of arteries (plaque) resulting in a thickening of the wall. Here we develop a mathematical model describing the biochemical processes of the formation of atherosclerotic plaque, which involves the interaction between pro-inflammatory mediators, modified low density lipoprotein, monocytes, macrophages, foam cells and high density lipoprotein. In addition, based on the outcomes of the biochemical model, we develop a plaque growth model that takes into account both the inward and outward expansion of the arterial walls. We examine the stability and ...
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    Atherosclerosis is a condition whereby fatty material is deposited in the walls of arteries (plaque) resulting in a thickening of the wall. Here we develop a mathematical model describing the biochemical processes of the formation of atherosclerotic plaque, which involves the interaction between pro-inflammatory mediators, modified low density lipoprotein, monocytes, macrophages, foam cells and high density lipoprotein. In addition, based on the outcomes of the biochemical model, we develop a plaque growth model that takes into account both the inward and outward expansion of the arterial walls. We examine the stability and bifurcations of this model in order to explore the clinical and medical implications of plaque growth
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    Journal Title
    ANZIAM Journal
    Volume
    57
    DOI
    https://doi.org/10.21914/anziamj.v57i0.10386
    Subject
    Biological Mathematics
    Mathematical Sciences
    Engineering
    Publication URI
    http://hdl.handle.net/10072/336574
    Collection
    • Journal articles

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