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dc.contributor.authorShi, Yu
dc.contributor.authorShi, Bingyang
dc.contributor.authorDass, Arun V Everest
dc.contributor.authorLu, Yiqing
dc.contributor.authorSayyadi, Nima
dc.contributor.authorKautto, Liisa
dc.contributor.authorWillows, Robert D
dc.contributor.authorChung, Roger
dc.contributor.authorPiper, James
dc.contributor.authorNevalainen, Helena
dc.contributor.authorWalsh, Bradley
dc.contributor.authorJin, Dayong
dc.contributor.authorPacker, Nicolle H
dc.date.accessioned2017-05-29T12:34:19Z
dc.date.available2017-05-29T12:34:19Z
dc.date.issued2016
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep37533
dc.identifier.urihttp://hdl.handle.net/10072/336664
dc.description.abstractProstate cancer is one of the male killing diseases and early detection of prostate cancer is the key for better treatment and lower cost. However, the number of prostate cancer cells is low at the early stage, so it is very challenging to detect. In this study, we successfully designed and developed upconversion immune-nanohybrids (UINBs) with sustainable stability in a physiological environment, stable optical properties and highly specific targeting capability for early-stage prostate cancer cell detection. The developed UINBs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and luminescence spectroscopy. The targeting function of the biotinylated antibody nanohybrids were confirmed by immunofluorescence assay and western blot analysis. The UINB system is able to specifically detect prostate cancer cells with stable and background-free luminescent signals for highly sensitive prostate cancer cell detection. This work demonstrates a versatile strategy to develop UCNPs based sustainably stable UINBs for sensitive diseased cell detection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Macmillan
dc.relation.ispartofpagefrom37533-1
dc.relation.ispartofpageto37533-11
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume6
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOther Physical Sciences
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0299
dc.titleStable Upconversion Nanohybrid Particles for Specific Prostate Cancer Cell Immunodetection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorEverest-Dass, Arun
gro.griffith.authorPacker, Nicki


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