dc.contributor.author | Rahman, M. | |
dc.contributor.author | Khatun, A. | |
dc.contributor.author | Uddin, Shaikh | |
dc.contributor.author | A. Shilpi, Jamil | |
dc.date.accessioned | 2017-05-29T12:33:24Z | |
dc.date.available | 2017-05-29T12:33:24Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1827-8620 | |
dc.identifier.uri | http://hdl.handle.net/10072/336816 | |
dc.description.abstract | Lannea coromandelica (Houtt.) Merr (Anacardiaceae), a Bangladeshi medicinal plant, has long been used in
indigenous medicine. The plant is reported to be used in the traditional medicine for all local swelling, pain
and inflammation and in the treatment of tumour, ulcers, cancer, sprains, bruises, skin diseases, and
dysentery. Both the leaves and the stem bark have painkilling and astringent property and so, mixed with
toothpowder for use in toothache. The leaves are copped as fodder and fed the livestock in inflammatory
and digestive problems. In this study, ethanol extracts of the leaves and stem bark of this traditionally
valuable medicinal plant were screened for analgesic activity on acetic acid induced Swiss-albino mice- Mus
musculus in vivo for the first time as well as studied for some important phytochemical groups. The dried
extracts were dissolved in 99.8% ethanol and qualitatively analysed for bioactive chemical groups-alkaloids,
glycosides, steroids, gums, reducing sugars, tannins, flavonoids, and saponins using standard chromogenic
reagents. The colour intensity or the precipitate formation was used as analytical responses to these tests.
Both the extracts were found to contain steroidal compounds, tannins, gums, reducing sugars, alkaloids as
well as flavonoids as their major bioactive phytochemical groups. In analgesic activity test, the bark extract
produced 92.92 % writhing inhibition and the leaf extract produced 95.14% writhing inhibition at the dose
of 250 mg/kg of body weight compared to the standard diclofenac Na that inhibit 78.54% writhing inhibition
at the dose of 25 mg/kg body weight by acetic acid induced writhing model in mice. Based on the results, it
could be concluded that the ethanol extract of Lannea coromandelica (Houtt.) Merr leaves and bark possess
significant analgesic activity and mood of action might involve a peripheral mechanism. The results
rationalize its use in folkloric remedies especially against pain and inflammation. | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Universita degli Studi di Salerno | |
dc.publisher.uri | http://pharmacologyonline.silae.it/front/archives_2016_1 | |
dc.relation.ispartofpagefrom | 146 | |
dc.relation.ispartofpageto | 152 | |
dc.relation.ispartofjournal | Pharmacologyonline | |
dc.relation.ispartofvolume | 1 | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences not elsewhere classified | |
dc.subject.fieldofresearchcode | 321499 | |
dc.title | Comparative effect of lannea coromandelica (houtt.) Merr. Leaves and stem barks on acetic acid induced pain model in mice and chromogenic reagents: exploring the analgesic potential and phytochemical groups | |
dc.type | Journal article | |
dc.type.description | C2 - Articles (Other) | |
dc.type.code | C - Journal Articles | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © The Author(s) 2016. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the author[s]. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Uddin, Shaikh J. | |