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dc.contributor.authorHeadrick, Johnen_US
dc.contributor.authorPeart, Jasonen_US
dc.contributor.authorC. Wang, Tinaen_US
dc.contributor.authorKwok, Wai-Mengen_US
dc.contributor.authorA. Auchampach, Johnen_US
dc.contributor.editorPA Boreaen_US
dc.date.accessioned2017-04-24T08:09:12Z
dc.date.available2017-04-24T08:09:12Z
dc.date.issued2010en_US
dc.date.modified2010-08-27T06:57:57Z
dc.identifier.isbn9789048131433en_US
dc.identifier.doi10.1007/978-90-481-3144-0_10en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33707
dc.description.abstractThe goal of this chapter is to review current theories regarding the potential involvement of the A3 receptor in mediating the actions of adenosine in the cardiovascular system. The Gi protein-coupled A3 adenosine receptor is the last adenosine receptor subtype to be discovered and remains poorly characterized in terms of its molecular biology and biological functions (Linden 1994). Recent evidence suggests that the A3 receptor may mediate the actions of adenosine to regulate vascular tone and angiogenesis, either directly or indirectly by stimulating the release of mediators from mast cells. Substantial evidence has accumulated to suggest that the A3 receptor is responsible for some of the beneficial effects of adenosine in reducing injury caused by ischemia and reperfusion. Readers are reminded that the A3 receptor has proven to be the most difficult adenosine receptor subtype to research due to its unique pharmacological properties and unusual species differences in terms of its pharmacology, tissue expression, and biological function (Linden 1994). The theories described in this chapter remain controversial and require additional verification as new tools become available to study this fascinating member of the adenosine receptor family.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeDordrechten_US
dc.publisher.urihttp://www.springerlink.comen_AU
dc.relation.ispartofbooktitleA3 Adenosine Receptors: from Cell Biology to Pharmacology and Therapeuticsen_US
dc.relation.ispartofchapter10en_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom189en_US
dc.relation.ispartofpageto208en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchClinical Pharmacology and Therapeuticsen_US
dc.subject.fieldofresearchcode111502en_US
dc.titleCardiovascular biology of the A3 adenosine receptoren_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2010
gro.hasfulltextNo Full Text


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