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dc.contributor.authorTong, Daniel King Hung
dc.contributor.authorLaw, Simon
dc.contributor.authorKwong, Dora Lai Wan
dc.contributor.authorChan, Kwok Wah
dc.contributor.authorLam, Alfred King Yin
dc.contributor.authorWong, Kam Ho
dc.contributor.editorCharles M. Balch
dc.date.accessioned2017-07-04T00:20:02Z
dc.date.available2017-07-04T00:20:02Z
dc.date.issued2010
dc.date.modified2010-08-27T06:58:14Z
dc.identifier.issn1068-9265
dc.identifier.doi10.1245/s10434-010-0995-2
dc.identifier.urihttp://hdl.handle.net/10072/33711
dc.description.abstractBackground. Whether the TNM staging system is applicable after neoadjuvant chemoradiation in esophageal cancer is controversial. The aim of this study was to evaluate the prognostic value of histopathological regression of the primary tumor in postchemoradiated patients. Materials and Methods. The pretherapeutic and pathological ypTNM stages of patients who have had neoadjuvant chemoradiation followed by esophagectomy were analyzed. The percentage of residual viable cells of the primary tumor (ypV) and other clinicopathological factors were tested for their prognostic value. Results. Of 175 recruited patients, 55 (31.4%) achieved pathological complete response. The median survival of these 55 patients was significantly longer than those with other disease stages (124.8 vs 21.1 months) (P/.001). Gender, ypT, ypN, ypTNM, and ypV stage were significant prognostic factors in univariate analysis. In patients without nodal metastases, the median survival in patients with residual viable cells in the primary tumor (ypV?) was 24.6 months, compared with that of 124.8 months in those with no viable cells (ypV0) (P = .043). In those who had nodal metastases, the median survival of patients with ypV0 and ypV? were 21.2 months and 17.4 months respectively (P = .37). Cox regression analysis showed that male gender, high percentage of residual viable cells (ypV), and positive nodal status (ypN1) were independent predictors of poor prognosis. Conclusions. In patients who underwent neoadjuvant chemoradiation therapy, histopathological regression of the primary tumor indicated by percentage of residual viable cells is an important prognostic factor in addition to nodal status and gender.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom2184
dc.relation.ispartofpageto2192
dc.relation.ispartofissue8
dc.relation.ispartofjournalAnnals of Surgical Oncology
dc.relation.ispartofvolume17
dc.rights.retentionN
dc.subject.fieldofresearchPathology (excl. oral pathology)
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode320220
dc.subject.fieldofresearchcode3211
dc.titleHistological regression of squamous esophageal carcinoma assessed by percentage of residual viable cells after neoadjuvant chemoradiation is an Important Prognostic Factor
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2010. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.


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