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dc.contributor.authorShariati-Kohbanani, M
dc.contributor.authorZare-Bidaki, M
dc.contributor.authorTaghavi, MM
dc.contributor.authorTaghipour, Z
dc.contributor.authorShabanizadeh, A
dc.contributor.authorKennedy, D
dc.contributor.authorDahim, H
dc.contributor.authorSalahshoor, MR
dc.contributor.authorJalili, C
dc.contributor.authorArababadi, M Kazemi
dc.date.accessioned2017-05-29T12:32:09Z
dc.date.available2017-05-29T12:32:09Z
dc.date.issued2016
dc.identifier.issn0145-5680
dc.identifier.urihttp://hdl.handle.net/10072/337214
dc.description.abstractOvarian cancer is the sixth most prevalent cancer in women and is considered the most lethal gynecological malignancy. It can be inherited as a familial disease but also has a strong spontaneous occurrence. Although the disease is associated with genome instability brought on by genetics and environmental factors there is evidence that mutations in the gene encoding for the breast cancer type 1 susceptibility protein (BRCA1) or its down-regulation are involved in its development. Down-regulation of BRCA1 expression by hypermethylation of its promoter may account for some cases of ovarian cancer but this does not explain the cause of the majority of the disease. This review explores the role of BRCA1 promoter hypermethylation and micro-RNAs (miRNA) involved in the regulation of BRCA1 and their role in ovarian cancer development as well as some of the exciting discoveries which could lead to targeting miRNA with a view to restoring BRCA1 expression in diseased tissues.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherC M B Association
dc.publisher.urihttps://www.cellmolbiol.org/index.php/CMB/article/view/774
dc.relation.ispartofpagefrom16
dc.relation.ispartofpageto23
dc.relation.ispartofissue1
dc.relation.ispartofjournalCellular and Molecular Biology
dc.relation.ispartofvolume62
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchEpigenetics (incl. genome methylation and epigenomics)
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310504
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode3204
dc.titleDNA Methylation and microRNA patterns are in association with the expression of BRCA1 in ovarian cancer
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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