Isolation and structure determination of two new hydrophobic microcystins from Microcystis sp. (CAWBG11)

Puddick, Jonathan; Prinsep, Michele R; Wood, Susanna A; Cary, S Craig; Hamilton, David P; Wilkins, Alistair L

doi:10.1016/j.phytol.2013.07.011

Author(s)

Puddick, Jonathan

Prinsep, Michele R

Wood, Susanna A

Cary, S Craig

Hamilton, David P

Wilkins, Alistair L

Griffith University Author(s)

Hamilton, David P.

Year published

2013

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Abstract

Two new hydrophobic microcystins, microcystin-FA (1) and microcystin-WA (2), were isolated from the cyanobacterium Microcystis sp. (CAWBG11). The structures were deduced using one- and two-dimensional nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The absolute stereochemistry of the amino acid residues in 1 and 2 was determined using the Advanced Marfey's method.Two new hydrophobic microcystins, microcystin-FA (1) and microcystin-WA (2), were isolated from the cyanobacterium Microcystis sp. (CAWBG11). The structures were deduced using one- and two-dimensional nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The absolute stereochemistry of the amino acid residues in 1 and 2 was determined using the Advanced Marfey's method.
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Journal Title

Phytochemistry Letters

Volume

Issue

DOI

https://doi.org/10.1016/j.phytol.2013.07.011

Subject

Medicinal and biomolecular chemistry

Medicinal and biomolecular chemistry not elsewhere classified

Plant biology

Pharmacology and pharmaceutical sciences

Publication URI

http://hdl.handle.net/10072/337281

Collection

Journal articles