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dc.contributor.authorWang, Chaoen_US
dc.contributor.authorYang, Xinzhouen_US
dc.contributor.authorMellick, Georgeen_US
dc.contributor.authorFeng, Yunen_US
dc.date.accessioned2017-05-29T12:31:57Z
dc.date.available2017-05-29T12:31:57Z
dc.date.issued2016en_US
dc.identifier.issn1948-7193en_US
dc.identifier.doi10.1021/acschemneuro.6b00245en_US
dc.identifier.urihttp://hdl.handle.net/10072/337427
dc.description.abstractParkinson’s disease (PD) is an incurable neurodegenerative disorder with a high prevalence rate worldwide. The fact that there are currently no proven disease-modifying treatments for PD underscores the urgency for a more comprehensive understanding of the underlying disease mechanism. Chemical probes have been proven to be powerful tools for studying biological processes. Traditional Chinese medicine (TCM) contains a huge reservoir of bioactive small molecules as potential chemical probes that may hold the key to unlocking the mystery of PD biology. The TCM-sourced chemical approach to PD biology can be advanced through the use of an emerging cytological profiling (CP) technique that allows unbiased characterization of small molecules and their cellular responses. This comprehensive technique, applied to chemical probe identification from TCM and used for studying the molecular mechanisms underlying PD, may inform future therapeutic target selection and provide a new perspective to PD drug discovery.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofpagefrom1628en_US
dc.relation.ispartofpageto1634en_US
dc.relation.ispartofjournalACS Chemical Neuroscienceen_US
dc.relation.ispartofvolume7en_US
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchcode030499en_US
dc.titleMeeting the Challenge: Using Cytological Profiling to Discover Chemical Probes from Traditional Chinese Medicines against Parkinson's Diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, School of Natural Sciencesen_US
gro.hasfulltextNo Full Text


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