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dc.contributor.authorWang, Chao
dc.contributor.authorYang, Xinzhou
dc.contributor.authorMellick, George D
dc.contributor.authorFeng, Yunjiang
dc.date.accessioned2017-05-29T12:31:57Z
dc.date.available2017-05-29T12:31:57Z
dc.date.issued2016
dc.identifier.issn1948-7193
dc.identifier.doi10.1021/acschemneuro.6b00245
dc.identifier.urihttp://hdl.handle.net/10072/337427
dc.description.abstractParkinson’s disease (PD) is an incurable neurodegenerative disorder with a high prevalence rate worldwide. The fact that there are currently no proven disease-modifying treatments for PD underscores the urgency for a more comprehensive understanding of the underlying disease mechanism. Chemical probes have been proven to be powerful tools for studying biological processes. Traditional Chinese medicine (TCM) contains a huge reservoir of bioactive small molecules as potential chemical probes that may hold the key to unlocking the mystery of PD biology. The TCM-sourced chemical approach to PD biology can be advanced through the use of an emerging cytological profiling (CP) technique that allows unbiased characterization of small molecules and their cellular responses. This comprehensive technique, applied to chemical probe identification from TCM and used for studying the molecular mechanisms underlying PD, may inform future therapeutic target selection and provide a new perspective to PD drug discovery.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom1628
dc.relation.ispartofpageto1634
dc.relation.ispartofjournalACS Chemical Neuroscience
dc.relation.ispartofvolume7
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classified
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchcode030499
dc.subject.fieldofresearchcode0304
dc.titleMeeting the Challenge: Using Cytological Profiling to Discover Chemical Probes from Traditional Chinese Medicines against Parkinson's Disease
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, School of Natural Sciences
gro.hasfulltextNo Full Text
gro.griffith.authorMellick, George
gro.griffith.authorFeng, Yun J.
gro.griffith.authorWang, Chao
gro.griffith.authorYang, Xinzhou


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