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dc.contributor.authorChemonges, Saul
dc.contributor.authorShekar, Kiran
dc.contributor.authorTung, John-Paul
dc.contributor.authorDunster, Kimble R
dc.contributor.authorDiab, Sara
dc.contributor.authorPlatts, David
dc.contributor.authorWatts, Ryan P
dc.contributor.authorGregory, Shaun D
dc.contributor.authorFoley, Samuel
dc.contributor.authorSimonova, Gabriela
dc.contributor.authorMcDonald, Charles
dc.contributor.authorHayes, Rylan
dc.contributor.authorBellpart, Judith
dc.contributor.authorTimms, Daniel
dc.contributor.authorChew, Michelle
dc.contributor.authorFung, Yoke L
dc.contributor.authorToon, Michael
dc.contributor.authorMaybauer, Marc O
dc.contributor.authorFraser, John F
dc.date.accessioned2017-06-02T04:23:21Z
dc.date.available2017-06-02T04:23:21Z
dc.date.issued2014
dc.identifier.issn2314-6133
dc.identifier.doi10.1155/2014/468309
dc.identifier.urihttp://hdl.handle.net/10072/338711
dc.description.abstractAnimal models of critical illness are vital in biomedical research. They provide possibilities for the investigation of pathophysiological processes that may not otherwise be possible in humans. In order to be clinically applicable, the model should simulate the critical care situation realistically, including anaesthesia, monitoring, sampling, utilising appropriate personnel skill mix, and therapeutic interventions. There are limited data documenting the constitution of ideal technologically advanced large animal critical care practices and all the processes of the animal model. In this paper, we describe the procedure of animal preparation, anaesthesia induction and maintenance, physiologic monitoring, data capture, point-of-care technology, and animal aftercare that has been successfully used to study several novel ovine models of critical illness. The relevant investigations are on respiratory failure due to smoke inhalation, transfusion related acute lung injury, endotoxin-induced proteogenomic alterations, haemorrhagic shock, septic shock, brain death, cerebral microcirculation, and artificial heart studies. We have demonstrated the functionality of monitoring practices during anaesthesia required to provide a platform for undertaking systematic investigations in complex ovine models of critical illness.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherHindawi Publishing
dc.relation.ispartofpagefrom468309-1
dc.relation.ispartofpageto468309-17
dc.relation.ispartofjournalBioMed Research International
dc.relation.ispartofvolume2014
dc.subject.fieldofresearchMedical Biotechnology not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchInformation and Computing Sciences
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode100499
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode08
dc.subject.fieldofresearchcode10
dc.titleOptimal management of the critically Ill: Anaesthesia, monitoring, data capture, and point-of-care technological practices in ovine models of critical care
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/3.0/
dc.description.versionPublished
gro.rights.copyright© 2014 Saul Chemonges et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorGregory, Shaun D.
gro.griffith.authorFung, Lin
gro.griffith.authorFraser, John F.


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