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dc.contributor.authorJ. Potter, Adamen_US
dc.contributor.authorKidd, Stephen P.en_US
dc.contributor.authorL. Edwards, Jenniferen_US
dc.contributor.authorL. Falsetta, Meganen_US
dc.contributor.authorA. Apicella, Michaelen_US
dc.contributor.authorP. Jennings, Michaelen_US
dc.contributor.authorG. McEwan, Alastairen_US
dc.date.accessioned2017-04-24T13:16:01Z
dc.date.available2017-04-24T13:16:01Z
dc.date.issued2009en_US
dc.date.modified2010-09-10T05:18:12Z
dc.identifier.issn00221899en_US
dc.identifier.doi10.1086/595737en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33884
dc.description.abstractIn Neisseria gonorrhoeae, the MerR family transcription factor NmlR activates 3 operons in response to disulfide stress. In the present study, we show that trxB, a monocistronic operon under the control of NmlR, encodes a functional thioredoxin reductase. It is shown that neisserial TrxB has biochemical properties similar to those of its homologue from Escherichia coli. Analysis of a trxB mutant of N. gonorrhoeae showed that it was more sensitive to disulfide stress and to stress induced by organic hydroperoxides, superoxide, and nitric oxide than wild-type gonococcus. TrxB was found to be essential for the microaerobic induction of aniA and norB, the genes encoding nitrite reductase and nitric oxide reductase, respectively. The importance of TrxB during natural infection was demonstrated by the fact that the survival of gonococci within human cervical epithelial cells, as well as biofilm formation on these cells, was greatly reduced for a trxB mutant compared with a wild-type strain.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherUniversity of Chicagoen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom227en_US
dc.relation.ispartofpageto235en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalThe Journal of Infectious Diseasesen_US
dc.relation.ispartofvolume199en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchcode060502en_US
dc.titleThioredoxin Reductase is Essential for Protection of Neisseria gonorrhoeae against Killing by Nitric Oxide and for Bacterial Growth during Interaction with Cervical Epithelial Cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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