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dc.contributor.authorHorton, R.en_US
dc.contributor.authorVidarsson, G.en_US
dc.contributor.authorVirji, M.en_US
dc.contributor.authorWilliams, N.en_US
dc.contributor.authorHeyderman, R.en_US
dc.date.accessioned2017-05-03T15:42:33Z
dc.date.available2017-05-03T15:42:33Z
dc.date.issued2009en_US
dc.date.modified2010-10-08T06:55:15Z
dc.identifier.issn08824010en_US
dc.identifier.doi10.1016/j.micpath.2009.01.009en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33894
dc.description.abstractDespite high carriage rates of Neisseria meningitidis, incidence of meningococcal disease remains low, partially due to development of natural immunity. We have previously demonstrated an inverse relationship between salivary anti-meningococcal IgA and disease incidence, but little is known about the contribution of IgA to immunity at mucosal surfaces. Here we show strong immunoreactivity by human salivary IgA against the meningococcal outer membrane porin, PorA. Monomeric anti-PorA IgA1 (humanized chimeric antibodies) but not IgG increased the association of unencapsulated serogroup B N. meningitidis (H44/76) with Chang (conjunctival) but not with either Detroit (pharyngeal) cells or with A549 (alveolar) epithelial cells. Association of encapsulated N. meningitidis was not increased. Epithelial binding of IgA was Fc fragment dependent and not inhibited by IgM. Together these data suggest the presence of a specific epithelial IgA receptor that could influence the effect of both naturally acquired and vaccine induced IgA antibodies at the epithelial surface.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent343141 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom253en_US
dc.relation.ispartofpageto260en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalMicrobial Pathogenesisen_US
dc.relation.ispartofvolume46en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchHumoural Immunology and Immunochemistryen_US
dc.subject.fieldofresearchMedical Bacteriologyen_US
dc.subject.fieldofresearchcode110705en_US
dc.subject.fieldofresearchcode110801en_US
dc.titleIgA1 antibodies specific for outer membrane protein PorA modulate the interaction between Neisseria meningitidis and the epitheliumen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2009
gro.hasfulltextFull Text


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