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dc.contributor.authorGuillon, Patriceen_US
dc.contributor.authorRuvoen-Clouet, Nathalieen_US
dc.contributor.authorMoullac-Vaidye, Beatriceen_US
dc.contributor.authorMarchandeau, Stephaneen_US
dc.contributor.authorPendu, Jacquesen_US
dc.date.accessioned2017-05-03T15:36:32Z
dc.date.available2017-05-03T15:36:32Z
dc.date.issued2009en_US
dc.date.modified2010-09-13T07:10:02Z
dc.identifier.issn09596658en_US
dc.identifier.doi10.1093/glycob/cwn098en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33911
dc.description.abstractRHDV (rabbit hemorrhagic disease virus) is a highly virulent calicivirus that has become a major cause of mortality in wild rabbit populations (Oryctolagus cuniculus). It binds to the histo-blood group antigen (HBGA) H type 2 which requires an alpha1,2fucosyltransferase for its synthesis. In rabbit, three alpha1,2fucosyltransferases genes are known, Fut1, Fut2, and Sec1. Nonfunctional alleles at any of these loci could potentially confer resistance to RHDV, similar to human FUT2 alleles that determine the nonsecretor phenotype and resistance to infection by various NoV strains. In this study, we looked for the presence of H type 2 on buccal epithelial cells of wild rabbits from two geographic areas under RHDV pressure and from one RHDV-free area. Some animals with diminished H type 2 expression were found in the three populations (nonsecretor-like phenotype). Their frequency markedly increased according to the RHDV impact, suggesting that outbreaks selected survivors with low expression of the virus ligand. Polymorphisms of the Fut1, Fut2, and Sec1 coding regions were determined among animals that either died or survived outbreaks. The Fut2 and Sec1 genes presented a high polymorphism and the frequency of one Sec1 allele was significantly elevated, over 6-fold, among survivors. Sec1 enzyme variants showed either moderate, low, or undetectable catalytic activity, whereas all variant Fut2 enzymes showed strong catalytic activity. This functional analysis of the enzymes encoded by each Fut2 and Sec1 allele suggests that the association between one Sec1 allele and survival might be explained by a deficit of alpha1,2fucosyltransferase expression rather than by impaired catalytic activity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherOxford University Pressen_US
dc.publisher.placeOxford, UKen_US
dc.relation.ispartofstudentpublicationYen_AU
dc.relation.ispartofpagefrom21en_US
dc.relation.ispartofpageto28en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalGlycobiologyen_US
dc.relation.ispartofvolume19en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchHost-Parasite Interactionsen_US
dc.subject.fieldofresearchVirologyen_US
dc.subject.fieldofresearchInnate Immunityen_US
dc.subject.fieldofresearchcode060307en_US
dc.subject.fieldofresearchcode060506en_US
dc.subject.fieldofresearchcode110707en_US
dc.titleAssociation between expression of the H histo-blood group antigen, alpha1,2fucosyltransferases polymorphism of wild rabbits, and sensitivity to rabbit hemorrhagic disease virusen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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