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  • Echocardiography and clozapine: Is current clinical practice inhibiting use of a potentially life-transforming therapy?

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    Author(s)
    Robinson, Gail
    Kisely, Steve
    Siskind, Dan
    Flanagan, Robert J
    Wheeler, Amanda J
    Griffith University Author(s)
    Wheeler, Amanda
    Year published
    2017
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    Abstract
    Approximately 33% of patients with schizophrenia are treatment-refractory, yet clozapine remains underused, even though it is the most effective treatment.1,2 One barrier is routine echocardiography, which in Australia is performed before clozapine initiation, six months afterwards and then annually.3 Elsewhere, such as in New Zealand, routine echocardiography is generally restricted to the initiation of therapy, while in the UK, it is not routine practice at all. Importantly, the latest guidelines from The Royal Australian and New Zealand College of Psychiatrists (RANZCP) suggest routine annual echocardiography adds little ...
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    Approximately 33% of patients with schizophrenia are treatment-refractory, yet clozapine remains underused, even though it is the most effective treatment.1,2 One barrier is routine echocardiography, which in Australia is performed before clozapine initiation, six months afterwards and then annually.3 Elsewhere, such as in New Zealand, routine echocardiography is generally restricted to the initiation of therapy, while in the UK, it is not routine practice at all. Importantly, the latest guidelines from The Royal Australian and New Zealand College of Psychiatrists (RANZCP) suggest routine annual echocardiography adds little to the detection of cardiomyopathy.4 We therefore review the evidence for routine echocardiography. This is particularly relevant to general practitioners (GPs) as they become more involved in managing patients on clozapine through shared-care arrangements.
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    Journal Title
    Australian Family Physician
    Volume
    46
    Issue
    3
    Publisher URI
    https://www.racgp.org.au/afp/2017/march/echocardiography-and-clozapine-is-current-clinical-practice-inhibiting-use-of-a-potentially-life-transforming-therapy/
    Copyright Statement
    © 2017 Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.
    Subject
    Clinical sciences
    Health care administration
    Publication URI
    http://hdl.handle.net/10072/339131
    Collection
    • Journal articles

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