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dc.contributor.authorLee, Naomien_US
dc.contributor.authorL. Radford-Smith, Grahamen_US
dc.contributor.authorForwood, Marken_US
dc.contributor.authorWong, Josephen_US
dc.contributor.authorR. Taaffe, Dennisen_US
dc.date.accessioned2017-04-24T09:04:59Z
dc.date.available2017-04-24T09:04:59Z
dc.date.issued2009en_US
dc.date.modified2010-09-13T07:10:29Z
dc.identifier.issn09148779en_US
dc.identifier.doi10.1007/s00774-009-0059-5en_AU
dc.identifier.urihttp://hdl.handle.net/10072/33919
dc.description.abstractCompromised skeletal status is a frequent finding in patients with Crohn's disease (CD), leading to increased fracture risk. Low body weight is associated with bone mineral density (BMD) in CD, although the relative importance of its components, lean and fat mass, is unclear. Muscle strength is also a predictor of BMD in nondiseased populations; however, its association with bone in CD is unknown. We examined the independent effects of body composition and muscle strength on regional and whole-body BMD in a cohort of CD patients. Sixty men and women, aged 22-72 years, with disease duration of 13 ᠷ years, underwent scanning of the spine, hip, forearm, and whole-body BMD by dual-energy X-ray absorptiometry (DXA). Lean tissue, appendicular muscle mass (AMM), and fat mass were derived by DXA and grip strength by dynamometry. Medical history, medication usage, clinical variables, and nutritional intake were obtained by questionnaire. Prevalence of osteopenia and osteoporosis was 32 and 17%, respectively, with osteopenia more common at the hip and osteoporosis more common at the spine. In multiple regression analyses, AMM was an independent predictor of whole-body and regional BMD whereas lean mass was an independent predictor at the hip. Neither grip strength nor fat mass was independently associated with BMD. Of the components of body composition, muscle mass was strongly associated with regional and whole-body BMD. Preserving or augmenting muscle mass in this population may be a useful strategy to preserve BMD and thereby reduce fracture risk.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeJapanen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom456en_US
dc.relation.ispartofpageto463en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalJournal of Bone and Mineral Metabolsimen_US
dc.relation.ispartofvolume27en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchOrthopaedicsen_US
dc.subject.fieldofresearchEndocrinologyen_US
dc.subject.fieldofresearchGastroenterology and Hepatologyen_US
dc.subject.fieldofresearchcode110314en_US
dc.subject.fieldofresearchcode110306en_US
dc.subject.fieldofresearchcode110307en_US
dc.titleBody composition and muscle strength as predictors of bone mineral density in Crohn's diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2009
gro.hasfulltextNo Full Text


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